Evidence map›Paper›PMID 32913679›Full record

ArticlePeerJ2020

Association of impaired fasting glucose and Type 2 Diabetes Mellitus with brain volume changes in Alzheimer's Disease patients analyzed by MRI: a retrospective study.

Weiwei Wang, Leongtim Wong, Lin Shi, Yishan Luo, Zhanhua Liang, Chunbo Dong, Qingwei Song, Tieli Liu, Qing Zhang, Ailian Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Weiwei Wang *Tianjin Medical University, Tianjin, China.
Leongtim Wong *BrainNow Research Institute, Shenzhen, Guangdong Province, China.
Lin ShiDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
Yishan LuoBrainNow Research Institute, Shenzhen, Guangdong Province, China.
Zhanhua LiangNeurology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Chunbo DongNeurology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Qingwei SongRadiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Tieli LiuRadiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Qing ZhangRadiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.
Ailian LiuRadiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Yanwei MiaoRadiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Jianlin WuRadiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.
Dalian Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CNAffiliated Zhongshan Hospital of Dalian University · CNChinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAlzheimer's disease (AD), impaired fasting glucose (IFG), and Type 2 diabetes mellitus (T2DM) were reported associated with smaller brain volumes. Nevertheless, the association of hyperglycemia with brain volume changes in AD patients remains unclear. To investigate this issue, structural magnetic resonance imaging was used to compare brain volumes among AD patients with different fasting glucose levels.

methodsEighty-five AD patients were divided into three groups based on their fasting glucose level as suggested by the American Diabetes Association: normal fasting glucose group (AD_NFG,

resultsCompared with the AD_IFG and AD_NFG groups, the volume of pons in AD_T2DM group was significantly smaller. Fasting glucose was negatively correlated with pontine volume.

conclusionsT2DM may exacerbate pontine atrophy in AD patients, and fasting glucose level is associated with pontine volume.

Indexed as

Alzheimer’s diseaseBrain atrophyBrain volumeFasting glucose levelHyperglycemiaImpaired fasting glucosePonsStructural MRIType 2 diabetes mellitus

Identifiers

PMID32913679
PMCPMC7456526
OpenAlexW3080723585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.