Evidence map›Paper›PMID 32913559›Full record

ArticleOncotarget2020

An integrative microenvironment approach for follicular lymphoma: roles of inflammatory cell subsets and immune-response polymorphisms on disease clinical course.

Guilherme Rossi Assis-Mendonça, André Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenço, Márcia Torresan Delamain, Suely Nonogaki, Vladmir Cláudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Cármino Antonio de Souza, Fernando Augusto Soares and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Guilherme Rossi Assis-MendonçaDepartment of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
André FattoriDepartment of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rafael Malagoli RochaMolecular Gynecology Laboratory, Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
Gustavo Jacob LourençoLaboratory of Cancer Genetics, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Márcia Torresan DelamainHematology and Hemotherapy Center, University of Campinas, Campinas, São Paulo, Brazil.
Suely NonogakiInstituto Adolfo Lutz, Secretaria de Estado da Saúde, São Paulo, Brazil.
Vladmir Cláudio Cordeiro de LimaDepartment of Medical Oncology, AC Camargo Cancer Center, São Paulo, Brazil.
Gisele Wally Braga ColleoniFederal University of São Paulo, São Paulo, Brazil.
Cármino Antonio de SouzaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Fernando Augusto SoaresRede D'Or Hospitals-Pathology Department, São Paulo, Brazil.
Carmen Silvia Passos LimaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
José VassalloDepartment of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Paulo · BRAC Camargo Hospital · BRD’Or Institute for Research and Education · BRInstituto Adolfo Lutz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the tumor microenvironment (TME) in follicular lymphoma (FL) has produced conflicting results due to assessment of limited TME subpopulations, and because of heterogeneous treatments among different cohorts. Also, important genetic determinants of immune response, such as single-nucleotide polymorphisms (SNPs), remain underexplored in this disease. We performed a detailed study of the TME in 169 FL biopsies using immunohistochemistry, encompassing lymphocytes, macrophages, and cytokines. We also genotyped 16 SNPs within key immune-response genes (

Indexed as

follicular lymphomaimmunohistochemistryprognosissingle nucleotide polymorphismstumor microenvironment

Identifiers

PMID32913559
PMCPMC7443366
OpenAlexW3056629504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.