ArticleAmerican journal of translational research2020
CoQ10 suppression of oxidative stress and cell senescence increases bone mass in orchiectomized mice.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Total Flavonoids of Rhizoma Drynariae Ameliorate Tendon-Bone Healing Following Anterior Cruciate Ligament Reconstruction in Rats by Activating the FSP1/CoQApplied biochemistry and biotechnology · 2026Article
- Effects of coenzyme Q10 on growth performance, rumen fermentation, blood metabolites, antioxidant status, and immune responses of pre-weaned Holstein dairy calves.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Ferroptosis Inhibition Enhances Osteoblast Activity: The Role of Liproxstatin-1 and Coenzyme Q10.International journal of molecular sciences · 2025Article
- Article
- The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies support the detrimental effects of oxidative stress and cell senescence on skeletal homeostasis. Coenzyme Q10 (CoQ10) acts as a scavenger for oxidative stress and protects mitochondrial activity from oxidative damage. However, it is unclear whether CoQ10 has a protective effect on osteoporosis caused by orchiectomy. To investigate suppression effect of antioxidant CoQ10 on osteoporosis in orchiectomized (ORX) mice, ORX mice were supplemented with/without CoQ10, and were compared with each other and with sham-operated mice. Our results showed that CoQ10 could prevent ORX-induced bone loss by inhibiting oxidative stress and cell senescence, subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results of this study not only reveal the mechanism of CoQ10 supplementation in anti-osteoporosis, but also provide experimental and theoretical basis for the clinical application of CoQ10 in the prevention of osteoporosis.
Indexed as
Identifiers
32913507PMC7476121W3084854663What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.