Evidence map›Paper›PMID 32913334›Full record

ReviewNature reviews. Drug discovery2021

Organs-on-chips: into the next decade.

Lucie A Low, Christine Mummery, Brian R Berridge, Christopher P Austin, Danilo A Tagle

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Drug discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 490 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
490citing papers in PubMed, 1 pooled it
43.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

490 citing papers in PubMed, 1 synthesis or guideline pooled it, 880 citations in OpenAlex.

  1. Pooled it
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  7. New approach methodologies in neurotherapeutics development.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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430 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lucie A LowNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. lucie.low@nih.gov.ORCID http://orcid.org/0000-0001-6082-8625
Christine MummeryLeiden University Medical Center, Leiden, Netherlands.
Brian R BerridgeNational Institute for Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA.
Christopher P AustinNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Danilo A TagleNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. danilo.tagle@nih.gov.ORCID http://orcid.org/0000-0003-0071-4612
National Institutes of Health · USLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process. These innovative devices could provide insights into normal human organ function and disease pathophysiology, as well as more accurately predict the safety and efficacy of investigational drugs in humans. Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near term, and in some cases replacements for them in the longer term. In the past decade, the OoC field has seen dramatic advances in the sophistication of biology and engineering, in the demonstration of physiological relevance and in the range of applications. These advances have also revealed new challenges and opportunities, and expertise from multiple biomedical and engineering fields will be needed to fully realize the promise of OoCs for fundamental and translational applications. This Review provides a snapshot of this fast-evolving technology, discusses current applications and caveats for their implementation, and offers suggestions for directions in the next decade.

Indexed as

Computer SimulationMicrochip Analytical ProceduresAnimalsAnimal Testing AlternativesBiomedical EngineeringCell Culture TechniquesCells, CulturedDrug DiscoveryHumans

Identifiers

PMID32913334
OpenAlexW3084374992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.