ArticleCommunications biology2020
Discovery of four Noggin genes in lampreys suggests two rounds of ancient genome duplication.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
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6 citing papers in PubMed, 20 citations in OpenAlex.
- The emergence ofFrontiers in cell and developmental biology · 2025Article
- The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.International journal of molecular sciences · 2024Article
- Loss of noggin1, a classic embryonic inducer gene, in elasmobranchs.Scientific reports · 2024Article
- ThreeFrontiers in cell and developmental biology · 2023Article
- Tissue and salinity specific NaScientific reports · 2021Article
- Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secreted protein Noggin1 was the first discovered natural embryonic inducer produced by cells of the Spemann organizer. Thereafter, it was shown that vertebrates have a whole family of Noggin genes with different expression patterns and functional properties. For example, Noggin1 and Noggin2 inhibit the activity of BMP, Nodal/Activin and Wnt-beta-catenin signalling, while Noggin4 cannot suppress BMP but specifically modulates Wnt signalling. In this work, we described and investigated phylogeny and expression patterns of four Noggin genes in lampreys, which represent the most basally divergent group of extant vertebrates, the cyclostomes, belonging to the superclass Agnatha. Assuming that lampreys have Noggin homologues in all representatives of another superclass of vertebrates, the Gnathostomata, we propose a model for Noggin family evolution in vertebrates. This model is in agreement with the hypotheses suggesting two rounds of genome duplication in the ancestor of vertebrates before the divergence of Agnatha and Gnathostomata.
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