ArticleScientific reports2020
Mating and blood-feeding induce transcriptome changes in the spermathecae of the yellow fever mosquito Aedes aegypti.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Transcriptional response of spermathecal secretory cells to mating and receipt of seminal fluid proteins iniScience · 2026Article
- A knockdown in the expression of a male-specific aminopeptidase impedes the male reproductive success of the mosquitoPhysiological entomology · 2025Article
- Mating of unfed, engorged, and partially to fully gravid Aedes aegypti (Diptera: Culicidae) female mosquitoes in producing viable eggs.Parasites & vectors · 2024Article
- Juvenile Hormone as a contributing factor in establishing midgut microbiota for fecundity and fitness enhancement in adult female Aedes aegypti.Communications biology · 2024Article
- Context-specific variation in life history traits and behavior ofFrontiers in insect science · 2024Review
- Molecular characterization, localization, and physiological roles of ITP and ITP-L in the mosquito,Frontiers in insect science · 2024Article
- Tyrosine transfer RNA levels and modifications during blood-feeding and vitellogenesis in the mosquito,bioRxiv : the preprint server for biology · 2023Article
- wMel Wolbachia alters female post-mating behaviors and physiology in the dengue vector mosquito Aedes aegypti.Communications biology · 2023Article
- Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract.BMC genomics · 2023Article
- Light and dark cycles modify the expression of clock genes in the ovaries of Aedes aegypti in a noncircadian manner.PloS one · 2023Article
- Abundances of transfer RNA modifications and transcriptional levels of tRNA-modifying enzymes are sex-associated in mosquitoes.Insect biochemistry and molecular biology · 2022Article
- Review
- Seminal fluid proteins induce transcriptome changes in the Aedes aegypti female lower reproductive tract.BMC genomics · 2021Article
- Characterization of the reproductive tract bacterial microbiota of virgin, mated, and blood-fed Aedes aegypti and Aedes albopictus females.Parasites & vectors · 2021Article
- Evaluation of Total Female and MaleInsects · 2021Article
- Uncovering the Worldwide Diversity and Evolution of the Virome of the MosquitoesMicroorganisms · 2021Article
- Male Age Influences Re-mating Incidence and Sperm Use in Females of the Dengue VectorFrontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Aedes aegypti mosquitoes are the primary vectors of numerous viruses that impact human health. As manipulation of reproduction has been proposed to suppress mosquito populations, elucidation of biological processes that enable males and females to successfully reproduce is necessary. One essential process is female sperm storage in specialized structures called spermathecae. Aedes aegypti females typically mate once, requiring them to maintain sperm viably to fertilize eggs they lay over their lifetime. Spermathecal gene products are required for Drosophila sperm storage and sperm viability, and a spermathecal-derived heme peroxidase is required for long-term Anopheles gambiae fertility. Products of the Ae. aegypti spermathecae, and their response to mating, are largely unknown. Further, although female blood-feeding is essential for anautogenous mosquito reproduction, the transcriptional response to blood-ingestion remains undefined in any reproductive tissue. We conducted an RNAseq analysis of spermathecae from unfed virgins, mated only, and mated and blood-fed females at 6, 24, and 72 h post-mating and identified significant differentially expressed genes in each group at each timepoint. A blood-meal following mating induced a greater transcriptional response in the spermathecae than mating alone. This study provides the first view of elicited mRNA changes in the spermathecae by a blood-meal in mated females.
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