Evidence map›Paper›PMID 32913222›Full record

ArticleJournal of exposure science & environmental epidemiology2021

Prenatal environmental exposures and associations with teen births.

Nicole V DeVille, Roxana Khalili, Jonathan I Levy, Susan A Korrick, Verónica M Vieira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole V DeVilleProgram in Public Health, College of Health Sciences, University of California, Irvine, Irvine, CA, USA. nhnvd@channing.harvard.edu.ORCID http://orcid.org/0000-0002-2199-8805
Roxana KhaliliProgram in Environmental Health Sciences, College of Health Sciences, University of California, Irvine, Irvine, CA, USA.
Jonathan I LevyDepartment of Environmental Health, Boston University School of Public Health, Boston, MA, USA.
Susan A Korrick *Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Verónica M Vieira *Program in Public Health, College of Health Sciences, University of California, Irvine, Irvine, CA, USA.

Funding

Training CoreP42ES007381 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHERR, DAVID H · 1995 to 2019
$46.1M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionR01ES014864 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI KORRICK, SUSAN A · 2006 to 2010
$3.3M
NIEHS NIH HHS P42 ES005947NIEHS NIH HHS P42 ES007381NIEHS NIH HHS R01 ES014864NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundChildren's prenatal exposure to multiple environmental chemicals may contribute to subsequent deficits in impulse control, predisposing them to risk-taking.

objectiveOur goal was to investigate associations between prenatal exposure mixtures and risk of teen birth, a manifestation of high-risk sexual activity, among 5865 girls (1st generation) born in southeast Massachusetts from 1992-1998.

methodsExposures included prenatal modeled polychlorinated biphenyls (PCBs), ρ,ρ'-dichlorodiphenyl dichloroethylene (DDE), hexachlorobenzene (HCB), lead (Pb), and mercury (Hg). We fit adjusted generalized additive models with multivariable smooths of exposure mixtures, 1st generation infant's birth year, and maternal age at 1st generation birth. Predicted odds ratios (ORs) for teen birth were mapped as a function of joint exposures. We also conducted sensitivity analyses among 1st generation girls with measured exposure biomarkers (n = 371).

resultsThe highest teen birth risk was associated with a mixture of high prenatal HCB, Hg, Pb, and PCB, but low DDE exposure, with similar associations in sensitivity analyses. The highest OR predicted for girls born in 1995 to mothers of median age (26 years) was at the 95 SIGNIFICANCE: Prenatal environmental chemical exposures and sociodemographic characteristics may interact to substantially increase risk of teen births.

Indexed as

Environmental PollutantsPolychlorinated BiphenylsPrenatal Exposure Delayed EffectsAdolescentAdultChildDichlorodiphenyl DichloroethyleneEnvironmental ExposureFemaleHumansInfantMassachusettsMaternal ExposurePregnancyDichlorodiphenyl DichloroethyleneEnvironmental PollutantsPolychlorinated BiphenylsEnvironmental mixturesMetalsModeled exposuresOrganochlorinesPrenatal exposuresTeen birth

Identifiers

PMID32913222
PMCPMC7943647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.