Evidence map›Paper›PMID 32913193›Full record

ArticleScientific reports2020

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry.

Isabel H X Ng, Alexandra F Bonthrone, Christopher J Kelly, Lucilio Cordero-Grande, Emer J Hughes, Anthony N Price, Jana Hutter, Suresh Victor, Andreas Schuh, Daniel Rueckert and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 29 citations in OpenAlex.

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  16. Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Isabel H X NgCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Alexandra F BonthroneCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Christopher J KellyCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Lucilio Cordero-GrandeCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Emer J HughesCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Anthony N PriceCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Jana HutterCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Suresh VictorCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Andreas SchuhBiomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.
Daniel RueckertBiomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.
Joseph V HajnalCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
John SimpsonPaediatric Cardiology Department, Evelina London Children's Hospital, St Thomas' Hospital, London, UK.
A David EdwardsCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Mary A RutherfordCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Dafnis BatalleCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Serena J CounsellCentre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK. serena.counsell@kcl.ac.uk.
King's College London · GBInstitute of Group Analysis · GBSt Thomas' Hospital · GBUniversidad Politécnica de Madrid · ES

Funding

British Heart Foundation FS/15/55/31649Department of HealthMedical Research Council MR/K006355/1Medical Research Council MR/L011530/1Medical Research Council MR/N026063/1Wellcome TrustWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO

Indexed as

AdultBrainCase-Control StudiesDiffusion Tensor ImagingFemaleGestational AgeHeart Defects, CongenitalHumansImage Processing, Computer-AssistedInfant, NewbornMaleOxygenProspective StudiesOxygen

Identifiers

PMID32913193
PMCPMC7483731
OpenAlexW3082986608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.