Evidence map›Paper›PMID 32913184›Full record

Observational studyNature communications2020

DNA methylation study of Huntington's disease and motor progression in patients and in animal models.

Ake T Lu, Pritika Narayan, Matthew J Grant, Peter Langfelder, Nan Wang, Seung Kwak, Hilary Wilkinson, Richard Z Chen, Jian Chen, C Simon Bawden and 14 more

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 4 countries.

Ake T Lu *Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-2866-7961
Pritika Narayan *Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand.ORCID http://orcid.org/0000-0002-8713-1470
Matthew J GrantApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand.
Peter LangfelderCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
Nan WangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
Seung KwakCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Hilary WilkinsonCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.ORCID http://orcid.org/0000-0002-0401-9329
Richard Z ChenCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Jian ChenCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.ORCID http://orcid.org/0000-0003-0595-5263
C Simon BawdenLivestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, SA, 5371, Australia.
Skye R RudigerLivestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, SA, 5371, Australia.
Marc CiosiInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Afroditi ChatziInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Alastair MaxwellInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Timothy A HoreDepartment of Anatomy, University of Otago, Dunedin, 9016, New Zealand.ORCID http://orcid.org/0000-0002-6735-225X
Jeff AaronsonCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Jim RosinskiCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Alicia PreissCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Thomas F VogtCHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA.
Giovanni CoppolaCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-2105-1061
Darren MoncktonInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.ORCID http://orcid.org/0000-0002-8298-8264
Russell G SnellApplied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand.
X William YangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-3705-7935
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. shorvath@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-4110-3589
CHDI Foundation · USUniversity of California, Los Angeles · USUniversity of Glasgow · GBUniversity of Auckland · NZSouth Australian Research and Development Institute · AUUniversity of Otago · NZ

Funding

Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR · 2009 to 2018
$7.4M
NINDS NIH HHS P30 NS062691
6 · The paper itself

Abstract

Although Huntington's disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EWAS) of human blood reveals that HD mutation status is significantly (p < 10

Indexed as

DNA MethylationEpigenesis, GeneticAdolescentAdultAgedAged, 80 and overAnimalsAnimals, Genetically ModifiedBehavior, AnimalCpG IslandsCross-Sectional StudiesDisease Models, AnimalDisease ProgressionFemaleFollow-Up StudiesGene Knock-In TechniquesHTT protein, humanHtt protein, mouseHuntingtin ProteinRecombinant Proteins

Identifiers

PMID32913184
PMCPMC7484780
OpenAlexW3084107046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.