Evidence map›Paper›PMID 32913128›Full record

ArticleThe Journal of biological chemistry2020

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins.

Christopher G Langendorf, Matthew T O'Brien, Kevin R W Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi X Y Ling, Toby A Dite, Sandra Galic, Kim Loh and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  9. Article
  10. Article
  11. Molecular Mechanisms Underlying CaInternational journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Complex roles of cAMP-PKA-CREB signaling in cancer.Experimental hematology & oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Christopher G LangendorfSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Matthew T O'BrienSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Kevin R W NgoeiSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Luke M McAloonSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Urmi DhagatSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia.
Ashfaqul HoqueSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Naomi X Y LingSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Toby A DiteSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Sandra GalicSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Kim LohSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia.
Michael W ParkerSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia.
Jonathan S OakhillSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Bruce E KempSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
John W ScottSt Vincent's Institute and Department of Medicine, University of Melbourne, Fitzroy, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia. Electronic address: jscott@svi.edu.au.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism. It is known to be activated by increases in intracellular Ca

Indexed as

Signal Transduction14-3-3 ProteinsAnimalsCalcium-Calmodulin-Dependent Protein Kinase KinaseCell Line, TumorChlorocebus aethiopsCOS CellsCyclic AMP-Dependent Protein KinasesEnzyme ActivationHumans14-3-3 ProteinsCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanCyclic AMP-Dependent Protein KinasesYWHAZ protein, human14-3-314-3-3 proteinadaptor proteinCa2+Ca2+-calmodulin–dependent protein kinase (CaMK)Ca2+-calmodulin–dependent protein kinase kinase-2 (CaMKK2)calmodulincalmodulin (CaM)CaMKK2cAMPcyclic AMP (cAMP)inhibition mechanismPKAprotein kinase A (PKA)

Identifiers

PMID32913128
PMCPMC7705300
OpenAlexW3086208975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.