ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reactivated thalamocortical plasticity alters neural activity in sensory-motor cortex during post-critical period.Progress in neurobiology · 2025Article
- Behavioral adaptations after unilateral whisker denervation.Behavioural brain research · 2025Article
- [Neuronal plasticity changes in the central amygdala and prelimbic cortex network in mice with chronic unpredictable mild stress-induced depression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms.Molecular neurobiology · 2024Review
- Resting-State Functional Magnetic Resonance Imaging Reveals the Effects of rTMS on Neural Activity and Brain Connectivity After Experimental Stroke.CNS neuroscience & therapeutics · 2024Article
- Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Genetic control of MRI contrast using the manganese transporter Zip14.Magnetic resonance in medicine · 2024Article
- Symmetry in frontal but not motor and somatosensory cortical projections.bioRxiv : the preprint server for biology · 2024Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Therapeutic effects of a novel electrode for transcranial direct current stimulation in ischemic stroke mice.Theranostics · 2024Article
- Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury.Neural regeneration research · 2023Article
- Connecting the lines after a stroke.eLife · 2022Article
- Article
- Peripheral Nerve Injury Induces Changes in the Activity of Inhibitory Interneurons as Visualized in Transgenic GAD1-GCaMP6s Rats.Biosensors · 2022Article
- Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.Nature communications · 2022Article
- Focusing on cognitive potential as the bright side of mental atypicality.Communications biology · 2022Review
- Compensatory functional connectome changes in a rat model of traumatic brain injury.Brain communications · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Injury induces synaptic, circuit, and systems reorganization. After unilateral amputation or stroke, this functional loss disrupts the interhemispheric interaction between intact and deprived somatomotor cortices to recruit deprived cortex in response to intact limb stimulation. This recruitment has been implicated in enhanced intact sensory function. In other patients, maladaptive consequences such as phantom limb pain can occur. We used unilateral whisker denervation in male and female mice to detect circuitry alterations underlying interhemispheric cortical reorganization. Enhanced synaptic strength from the intact cortex via the corpus callosum (CC) onto deep neurons in deprived primary somatosensory barrel cortex (S1BC) has previously been detected. It was hypothesized that specificity in this plasticity may depend on to which area these neurons projected. Increased connectivity to somatomotor areas such as contralateral S1BC, primary motor cortex (M1) and secondary somatosensory cortex (S2) may underlie beneficial adaptations, while increased connectivity to pain areas like anterior cingulate cortex (ACC) might underlie maladaptive pain phenotypes. Neurons from the deprived S1BC that project to intact S1BC were hyperexcitable, had stronger responses and reduced inhibitory input to CC stimulation. M1-projecting neurons also showed increases in excitability and CC input strength that was offset with enhanced inhibition. S2 and ACC-projecting neurons showed no changes in excitability or CC input. These results demonstrate that subgroups of output neurons undergo dramatic and specific plasticity after peripheral injury. The changes in S1BC-projecting neurons likely underlie enhanced reciprocal connectivity of S1BC after unilateral deprivation consistent with the model that interhemispheric takeover supports intact whisker processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.