Evidence map›Paper›PMID 32913038›Full record

ReviewPostgraduate medical journal2021

Is HbA1c an ideal biomarker of well-controlled diabetes?

Georgia Kaiafa, Stavroula Veneti, George Polychronopoulos, Dimitrios Pilalas, Stylianos Daios, Ilias Kanellos, Triantafyllos Didangelos, Stamatina Pagoni, Christos Savopoulos

Full text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Postgraduate medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Medically Tailored Grocery Delivery for Food Pantry Clients with Diabetes.Journal of nutrition education and behavior · 2025
    Article
  19. Narrative Review: Continuous Glucose Monitoring (CGM) in Older Adults with Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georgia KaiafaFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece gdkaiafa@yahoo.gr.ORCID http://orcid.org/0000-0001-8000-4500
Stavroula VenetiFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.
George PolychronopoulosFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.
Dimitrios PilalasFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.
Stylianos DaiosInternal Medicine Department, General Hospital of Serres, Greece.
Ilias KanellosFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.
Triantafyllos DidangelosFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.
Stamatina Pagoni3rd Department of Internal Medicine, "G. Gennimatas" General Hospital of Athens, Greece.
Christos SavopoulosFirst Propedeutic Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-7970-2464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HbA1c is a biomarker with a central role in the diagnosis and follow-up of patients with diabetes, although not a perfect one. Common comorbidities encountered in patients with diabetes mellitus, such as renal insufficiency, high output states (iron deficiency anaemia, haemolytic anaemia, haemoglobinopathies and pregnancy) and intake of specific drugs could compromise the sensitivity and specificity of the biomarker. COVID-19 pandemic poses a pressing challenge for the diabetic population, since maintaining optimal blood glucose control is key to reduce morbidity and mortality rates. Alternative methods for diabetes management, such as fructosamine, glycosylated albumin and device-based continuous glucose monitoring, are discussed.

Indexed as

BiomarkersBlood GlucoseBlood Glucose Self-MonitoringCOVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Glycated HemoglobinHumansPredictive Value of TestsBiomarkersBlood GlucoseGlycated HemoglobinAnaemiaDiabetes & endocrinologyGeneral diabetesHaematology

Identifiers

PMID32913038
PMCPMC10016911

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read31
identifiers read5
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.