ArticleNeurology2020
The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage.
Open access · greenAbstract read
In one paragraph
Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Pooled it
- Diagnosis, Prevention, Management, and Prognostication of Delirium in Acute-Care Neurosurgical Patients: A Systematic Scoping Review.Neurocritical care · 2026Review
- The Impact of Socioeconomic Status on Decision on Withdrawal of Life-sustaining Treatments in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2025Article
- Neuroimaging Markers of Brain Reserve and Associations with Delirium in Patients with Intracerebral Hemorrhage.Neurocritical care · 2025Article
- Validating the Fluctuating Mental Status Evaluation in Neurocritically Ill Patients With Acute Stroke.Critical care medicine · 2024Article
- Time trends in mechanical thrombectomy (2017-2021): do real-world data reflect advances in evidence?Frontiers in neurology · 2024Article
- A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients.Neurocritical care · 2023Article
- Delirium detection using wearable sensors and machine learning in patients with intracerebral hemorrhage.Frontiers in neurology · 2023Article
- Article
- Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage.Journal of critical care · 2021Article
- Prognostication after intracerebral hemorrhage: a review.Neurological research and practice · 2021Review
- End-of-Life Care Decision-Making in Stroke.Frontiers in neurology · 2021Review
- Factors influencing withdrawal of life-sustaining treatments in patients with severe acquired brain injuries: a scoping review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Michael E ReznikFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN. Michael_Reznik@brown.edu.ORCID 0000-0002-9251-5049
Scott MoodyFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0001-6490-9924
Kayleigh MurrayFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Samantha CostaFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Brian Mac GroryFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Tracy E MadsenFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Ali MahtaFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Linda C WendellFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Bradford B ThompsonFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Shyam S RaoFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Christoph StretzFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Kevin N ShethFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
David Y HwangFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Darin B ZahuranecFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Matthew SchragFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0001-7048-0503
Lori A DaielloFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Wael F AsaadFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-4406-9096
Richard N JonesFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-1049-218X
Karen L FurieFrom the Department of Neurology (M.E.R., S.M., K.M., S.C., B.M.G., A.M., L.C.W., B.B.T., S.S.R., C.S., L.A.D., R.N.J., K.L.F.), Department of Neurosurgery (M.E.R., A.M., L.C.W., B.B.T., S.S.R., W.F.A.), Department of Emergency Medicine (T.E.M.), Section of Medical Education (L.C.W.), and Department of Psychiatry and Human Behavior (R.N.J.), Alpert Medical School, Brown University, Providence, RI; Department of Neurology (K.N.S., D.Y.H.), Yale School of Medicine, New Haven, CT; Department of Neurology and Stroke Program (D.B.Z.), Michigan Medicine, Ann Arbor; and Department of Neurology (M.S.), Vanderbilt University School of Medicine, Nashville, TN.
Vanderbilt University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3MBlood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorder:Cognitive Recovery after Elective SurgeryR01AG058648 · NIA · RHODE ISLAND HOSPITAL · PI DAIELLO, LORI A · 2019 to 2024
$4.2MNCATS NIH HHS UL1 TR001863NIA NIH HHS R01 AG058648
Abstract
objectiveTo determine the impact of delirium on withdrawal of life-sustaining treatment (WLST) after intracerebral hemorrhage (ICH) in the context of established predictors of poor outcome, using data from an institutional ICH registry.
methodsWe performed a single-center cohort study on consecutive patients with ICH admitted over 12 months. ICH features were prospectively adjudicated, and WLST and corresponding hospital day were recorded retrospectively. Patients were categorized using DSM-5 criteria as never delirious, ever delirious (either on admission or later during hospitalization), or persistently comatose. We determined the impact of delirium on WLST using Cox regression models adjusted for demographics and ICH predictors (including Glasgow Coma Scale score), then used logistic regression with receiver operating characteristic curve analysis to compare the accuracy of ICH score-based models with and without delirium category in predicting WLST.
resultsOf 311 patients (mean age 70.6 ± 15.6, median ICH score 1 [interquartile range 1-2]), 50% had delirium. WLST occurred in 26%, and median time to WLST was 1 day (0-6). WLST was more frequent in patients who developed delirium (adjusted hazard ratio 8.9 [95% confidence interval (CI) 2.1-37.6]), with high rates of WLST in both early (occurring ≤24 hours from admission) and later delirium groups. An ICH score-based model was strongly predictive of WLST (area under the curve [AUC] 0.902 [95% CI 0.863-0.941]), and the addition of delirium category further improved the model's accuracy (AUC 0.936 [95% CI 0.909-0.962],
conclusionDelirium is associated with WLST after ICH regardless of when it occurs. Further study on the impact of delirium on clinician and surrogate decision-making is warranted.
Indexed as
Outcome and Process Assessment, Health CareRegistriesAgedAged, 80 and overCerebral HemorrhageCohort StudiesDeliriumFemaleHumansLife Support CareMaleMiddle AgedPrognosisWithholding Treatment
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.