ArticleBMJ open2020
Seizure prevalence in children aged up to 3 years: a longitudinal population-based cohort study in Japan.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Evaluation of the appropriateness of pediatric seizure Management in Primary Care Clinics.Epilepsy & behavior reports · 2026Article
- Active Seizures on Arrival at the Hospital During Ambulance Transfers in Children: A Five-Year Record Review.Cureus · 2026Article
- Factors Related to Febrile Seizures Among Children at Abdul Moeloek Regional Hospital in Lampung Province.The Malaysian journal of medical sciences : MJMS · 2025Article
- Association between maternal folate levels and febrile seizures in early childhood from the Japan Environment and Children's Study.Scientific reports · 2025Article
- Gestational hypertension increases risk of seizures in children and mice.The Journal of clinical investigation · 2025Article
- Association of Encephalitis With Viruses in Cerebrospinal Fluid in Children: A Case Series.Cureus · 2025Article
- Identification of Genetic Variants in Status Epilepticus Associated With Fever.Brain and behavior · 2025Observational
- Investigating the effect of guided self-help through social networks on post-traumatic stress disorder symptoms and resilience of mothers with children suffering from febrile seizures.Journal of education and health promotion · 2025Article
- Seasonal Trend of Viral Prevalence and Incidence of Febrile Convulsion: A Korea Public Health Data Analysis.Children (Basel, Switzerland) · 2023Article
- Clinical and laboratory characteristics of complex febrile seizures in the acute phase: a case-series study in Japan.BMC neurology · 2023Article
- The Negative Association between Breastfeeding Duration and Infant Febrile Seizure: A Retrospective Case-Control Study.International journal of environmental research and public health · 2022Article
- Clinical spectrum and neuroimaging findings in children with seizures: A five-year retrospective study.Iranian journal of child neurology · 2022Article
- The recent characteristics of influenza-related hospitalization in Japanese children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the prevalence of seizures/febrile seizures in children up to 3 years of age and examine the effects of gestational age at birth on the risk for febrile seizures.
designRetrospective longitudinal population-based cohort study.
settingKobe City public health center, Kobe, Japan, from 2010 to 2018.
participantsChildren who underwent a medical check-up at 3 years of age.
methodsInformation regarding seizures was collected from the parents of 96 014 children. We identified the occurrence of seizure/febrile seizure in 74 017 children, whose gestational ages at birth were noted. We conducted a multivariate analysis with the parameter, gestational age at birth, to analyse the risk of seizure. We also stratified the samples by sex and birth weight (<2500 g or not) and compared the prevalence of seizure between those with the term and late preterm births.
resultsThe prevalence of seizure was 12.1% (11.8%-12.3%), 13.2% (12.2%-14.4%), 14.6% (12.4%-17.7%) and 15.7% (10.5%-22.8%) in children born at 37-41, 34-36, 28-33 and 22-27 gestational weeks, respectively. The prevalence of febrile seizures was 9.0% (8.8%-9.2%), 10.5% (9.5%-11.5%), 11.8% (9.7%-14.5%) and 11.2% (6.9%-17.7%) in children born at 37-41, 34-36, 28-33 and 22-27 gestational weeks, respectively. Male was an independent risk factor for seizures (OR: 1.15, 95% CI 1.09 to 1.20; absolute risk increase 0.014, 95% CI 0.010 to 0.019) and febrile seizures (OR: 1.21, 95% CI 1.15 to 1.28; absolute risk increase 0.016, 95% CI 0.012 to 0.020), respectively. Late preterm birth was not associated with an increased risk of seizure/febrile seizure.
conclusionsAlthough very preterm birth may increase the risk of seizure/febrile seizure, the risk associated with late preterm birth is considerably small and less than that associated with male.
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