Evidence map›Paper›PMID 32912949›Full record

ArticleBMJ open2020

What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation.

Chloe Thomas, Alan Brennan, Edward Goka, Hazel Y Squires, Gilly Brenner, David Bagguley, Helen Buckley Woods, Michael Gillett, Joanna Leaviss, Mark Clowes and 3 more

Abstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Cost-effectiveness of the ABCStroke pathway in ischaemic stroke care: a UK pilot analysis.European heart journal. Quality of care & clinical outcomes · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Clinical Considerations for Healthcare Provider-Administered Lipid-Lowering Medications.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Diabetes and Cardiovascular Diseases Risk Assessment in Community Pharmacies: An Implementation Study.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chloe ThomasSchool of Health & Related Research, University of Sheffield, Sheffield, UK c.thomas@sheffield.ac.uk.ORCID 0000-0001-8704-3262
Alan BrennanSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Edward GokaSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Hazel Y SquiresSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Gilly BrennerRotherham Metropolitan Borough Council, Rotherham, Rotherham, UK.
David BagguleySchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Helen Buckley WoodsSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Michael GillettSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Joanna LeavissSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Mark ClowesSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Laura HeathcoteSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Katy CooperSchool of Health & Related Research, University of Sheffield, Sheffield, UK.
Penny BreezeSchool of Health & Related Research, University of Sheffield, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the cost savings and health benefits of improving detection of individuals at high risk of cardiovascular disease (CVD) in England, to determine to which patient subgroups these benefits arise, and to compare different strategies for subsequent management.

designAn economic analysis using the School for Public Health Research CVD Prevention Model.

settingEngland 2018.

participantsAdults aged 16 and older with one or more high cardiovascular risk conditions, including hypertension, diabetes, non-diabetic hyperglycaemia, atrial fibrillation, chronic kidney disease and high cholesterol.

interventionsDetection of 100% of individuals with CVD high risk conditions compared with current levels of detection in England. Detected individuals are assumed to be managed either according to current levels of care or National Institute of Health and Care Excellence (NICE) guidelines.

main outcome measuresIncremental and cumulative costs, savings, quality adjusted life years (QALYs), CVD cases, and net monetary benefit, from a UK NHS and Personal Social Services perspective.

results£68 billion could be saved, 4.9 million QALYs gained and 3.4 million cases of CVD prevented over 25 years if all individuals in England with the six CVD high risk conditions were diagnosed and subsequently managed at current levels. Additionally, if all detected individuals were managed according to NICE guidelines, total savings would be £61 billion, 8.1 million QALYs would be gained and 5.2 million CVD cases prevented. Most benefits come from detection of high cholesterol in the short term and diabetes in the long term.

conclusionsSubstantial cost savings and health benefits would accrue if all individuals with conditions that increase CVD risk could be diagnosed, with detection of undiagnosed diabetes producing greatest benefits. Ensuring all conditions are managed according to NICE guidelines would further increase health benefits. Projected cost-savings could be invested in developing acceptable and cost-effective solutions for improving detection and management.

Indexed as

Cardiovascular DiseasesAdolescentAdultCost-Benefit AnalysisCost SavingsEnglandHeart Disease Risk FactorsHumansRisk Factorscardiologyhealth economicspreventive medicinepublic healthstroke medicine

Identifiers

PMID32912949
PMCPMC7488844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.