Evidence map›Paper›PMID 32912894›Full record

ArticleBMJ case reports2020

Angioedema, ACE inhibitor and COVID-19.

Ekjot Grewal, Bayu Sutarjono, Ibbad Mohammed

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Alterations in plasma proteome during acute COVID-19 and recovery.Molecular medicine (Cambridge, Mass.) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ekjot GrewalDepartment of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA.ORCID http://orcid.org/0000-0001-6073-6296
Bayu SutarjonoDepartment of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA b.sutarjono@saba.edu.
Ibbad MohammedDepartment of Emergency Medicine, Brookdale University Hospital Medical Center, Brooklyn, New York, USA.
Brookdale University Hospital and Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2, the virus responsible for COVID-19, binds to the ACE2 receptors. ACE2 is thought to counterbalance ACE in the renin-angiotensin system. While presently it is advised that patients should continue to use ACE inhibitors or angiotensin receptor blockers, questions still remain as to whether adverse effects are potentiated by the virus. Here, we report a case of a 57-year-old man, unknowingly with COVID-19, who presented to the emergency department with tongue swelling, shortness of breath and difficulty in speaking following 4 months taking benazepril, an ACE inhibitor. Finally, we also describe possible pathways that exist for SARS-CoV-2 to interact with the mechanism behind angioedema.

Indexed as

BetacoronavirusAngioedemaAngiotensin-Converting Enzyme InhibitorsAnti-Allergic AgentsBenzazepinesCoronavirus InfectionsCOVID-19Diagnosis, DifferentialDiphenhydramineFamotidineHistamine H2 AntagonistsHumansMaleMiddle AgedPandemicsPneumonia, ViralAngiotensin-Converting Enzyme InhibitorsAnti-Allergic AgentsbenazeprilBenzazepinesDiphenhydramineFamotidineHistamine H2 AntagonistsTranexamic Acidemergency medicinepneumonia (infectious disease)unwanted effects / adverse reactions

Identifiers

PMID32912894
PMCPMC7482445
OpenAlexW3085764892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.