ArticleAJNR. American journal of neuroradiology2020
Maternal Anxiety and Depression during Late Pregnancy and Newborn Brain White Matter Development.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05295264 (Active Pregnancy. Mental and Emotional Health Care to Pregnant Woman During and After COVID-19), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Active Pregnancy. Mental and Emotional Health Care to Pregnant Woman During and After COVID-19
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- Association of prenatal depression and anxiety with cortical development and behavioral outcomes in 8-year-old children.Journal of affective disorders · 2026Article
- Perinatal mental health and its social determinants: qualitative findings from rural Telangana.BMC psychiatry · 2026Article
- Prenatal parental mental health and neurodevelopment in children with congenital heart disease.Pediatric research · 2026Review
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- The initial report of prospective study for maternal and fetal outcomes to investigate the safety of multifetal pregnancy reduction in Japan.The journal of obstetrics and gynaecology research · 2025Article
- Prenatal Adversity and Neonatal White Matter Microstructure Independently Relate to Language Outcomes at Age 2 Years.The Journal of pediatrics · 2025Article
- Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy.Frontiers in human neuroscience · 2025Article
- Can Pregnancy Experience Predict Birth Experience, Postpartum Depression and Anxiety? A Prospective Descriptive Study.Nursing open · 2024Article
- Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development.Pediatric research · 2024Review
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Prenatal Maternal Psychological Distress During the COVID-19 Pandemic and Newborn Brain Development.JAMA network open · 2024Article
- Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure.Human brain mapping · 2023Article
- Examining resting-state network connectivity in children exposed to perinatal maternal adversity using anatomically weighted functional connectivity (awFC) analyses; A preliminary report.Frontiers in neuroscience · 2023Article
- Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Concerns of High-Risk Pregnancies During Pandemic: COVID-19 and Fear of Birth.Florence Nightingale journal of nursing · 2022Article
- Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
background and purposeAnxiety and depression during pregnancy have been associated with an increased risk of adverse neurodevelopmental outcomes in offspring. We aimed to study the in utero effects of maternal anxiety and depression on early brain development. MATERIALS AND
methodsPregnant women were recruited at ∼36 weeks of gestation for this prospective study. They were assessed for anxiety symptoms by the State-Trait Anxiety Inventory and for depression symptoms by the Beck Depression Inventory, 2nd Edition. After delivery, infant underwent an MR imaging examination of the brain without sedation, including DTI, for evaluation of white matter (WM) development. Infant fractional anisotropy values, a putative marker of WM integrity, were correlated with the mothers' State-Trait Anxiety Inventory and Beck Depression Inventory scores by using both tract-based spatial statistics and ROI methods.
resultsThirty-four infants were included in this study. Both maternal State-Anxiety and Trait-Anxiety scores negatively correlated (
conclusionsHigher maternal anxiety and depression symptom scores during late pregnancy were associated with lower estimated infant brain WM development, which indicated in utero influences of maternal mental health during pregnancy on the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.