ArticleBMJ open diabetes research & care2020
Decrease in Choroidal Vascularity Index of Haller's layer in diabetic eyes precedes retinopathy.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Choroidal Vascular Remodeling After Loading Injections of Faricimab in Diabetic Macular Edema.Translational vision science & technology · 2026Article
- A Pilot Study on Structural Changes of Choroidal Vasculature Following Intravitreal Anti-VEGF Injection in Neovascular Age-Related Macular Degeneration: Faricimab vs Ranibizumab.Journal of clinical medicine · 2025Article
- Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia.Frontiers in cell and developmental biology · 2025Article
- Choroidal vascularity index in health and systemic diseases: a systematic review.International journal of retina and vitreous · 2024Review
- Article
- Artificial Intelligence-Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy.Translational vision science & technology · 2024Article
- Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy.Translational vision science & technology · 2024Article
- Choroidal Changes in Patients with Diabetic Retinopathy: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Validation of reliability, repeatability and consistency of three-dimensional choroidal vascular index.Scientific reports · 2024Article
- Comparison of Choroidal Vascularity Index, Retinal, and Optic Nerve Changes in Diabetes Mellitus Patients Without Diabetic Retinopathy.Beyoglu eye journal · 2024Article
- Retinal and Choroidal Vascularization Parameters in Patients with Type 2 Diabetes Without Diabetic Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- Postoperative choroidal vascularity index after the management of macula-off rhegmatogenous retinal detachment.International journal of retina and vitreous · 2023Review
- Detection of macular ganglion cell complex loss and correlation with choroidal thickness in chronic and recurrent central serous chorioretinopathy.International journal of ophthalmology · 2023Article
- Choroidal structural alterations in diabetic patients in association with disease duration, HbA1c level, and presence of retinopathy.International ophthalmology · 2022Article
- Vascular Changes of the Choroid and Their Correlations With Visual Acuity in Pathological Myopia.Investigative ophthalmology & visual science · 2022Article
- Early choroidal changes detected by swept-source OCT in type 2 diabetes and their association with diabetic kidney disease.BMJ open diabetes research & care · 2022Article
- Correlation of choroidal thickness with age in healthy subjects: automatic detection and segmentation using a deep learning model.International ophthalmology · 2022Article
- Choroidal Assessment in Patients with Type 2 Diabetes Mellitus and Non-Proliferative Diabetic Retinopathy by Swept-Source Ocular Coherence Tomography and Image Binarization.Medicina (Kaunas, Lithuania) · 2022Article
- Volumetric quantification of choroid and Haller's sublayer using OCT scans: An accurate and unified approach based on stratified smoothing.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe study aimed to evaluate Choroidal Vascularity Index (CVI) of Haller's and Sattler's layers and their relationships with choroidal and retinal thickness, volumes measured on enhanced depth imaging-optical coherence tomography (OCT) scans in the eyes of patients without diabetes, patients with diabetes with no diabetic retinopathy (DR) and patients with diabetes and DR. RESEARCH DESIGN AND
methodsRetrospective analysis of 165 eyes from 84 Singapore Indian Eye Study-2 study participants (group 1: no diabetes, group 2: diabetes with no DR and group 3: with DR). Groups 1 and 2 were matched by age and gender from group 3.
resultsIn the eyes of patients with diabetes without DR, the macular CVI of Haller's but not Sattler's layer was significantly reduced compared with eyes of patients without diabetes. Eyes with >5 years of diabetes have significantly decreased CVI of Sattler's layers (mean difference=0.06 ± 0.10, p=0.04) and also decreased subfoveal choroidal volume (mean difference=0.89 ± 0.16 mm
conclusionDiabetic eyes without DR had significantly lower CVI of macular Haller's layer than those of healthy controls. With a longer duration of diabetes, CVI of subfoveal Sattler's layer and choroidal volume continue to decrease, irrespective of diabetic control, suggesting that early diabetic choroidopathy mainly affects larger choroidal veins initially before medium-sized arterioles. The CVI of macular Haller's layer could potentially be used as a marker on spectral domain OCT imaging in newly diagnosed patients with diabetes for the onset of DR and as a possible prognostication tool in diabetic eyes. Future prospective longitudinal studies in diabetic eyes would be useful in establishing the relationship between CVIs of Haller's and Sattler's layer with visual acuity as a marker of photoreceptor health and visual prognosis.
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