Observational studyNutrition, metabolism, and cardiovascular diseases : NMCD2020
Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the multicentre Italian CORIST Study.
Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04907890 (Long Term Outcomes in COVID-19 Patients Recruited in the CORIST Project), which is not on this map. Cited by 110 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 8 pooled it
4.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Outcomes in COVID-19 Patients Recruited in the CORIST Project: Longitudinal Data and Case-control Study
Who cites it
110 citing papers in PubMed, 8 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Barriers and Facilitators to Patient Acceptance of Artificial Intelligence in Health Care: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Association of Obesity With COVID-19 Severity and Mortality: An Updated Systemic Review, Meta-Analysis, and Meta-Regression.Frontiers in endocrinology · 2022Pooled it
- The isolated effect of age on the risk of COVID-19 severe outcomes: a systematic review with meta-analysis.BMJ global health · 2021Pooled it
- Pooled it
- The effect of cardiovascular disease and acute cardiac injury on fatal COVID-19: a meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence.BMC medicine · 2021Pooled it
- Chronic Diseases as a Predictor for Severity and Mortality of COVID-19: A Systematic Review With Cumulative Meta-Analysis.Frontiers in medicine · 2021Pooled it
- RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies.Vascular pharmacology · 2020Pooled it
- Death by SARS-CoV 2: a Romanian COVID-19 multi-centre comorbidity study.Scientific reports · 2020Trial
- Article
- Sex-Specific Risk Factors and Predictors of Major Adverse Cardiac and Cerebrovascular Events in Heart Failure with Preserved Ejection Fraction with SARS-CoV-2 Infection: A Nationwide Analysis.Journal of clinical medicine · 2025Article
- Surfactant-derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia.ERJ open research · 2024Article
- The predictive power of data: machine learning analysis for Covid-19 mortality based on personal, clinical, preclinical, and laboratory variables in a case-control study.BMC infectious diseases · 2024Article
- Assessing the impact of vaccines on COVID-19 efficacy in survival rates: a survival analysis approach for clinical decision support.Frontiers in public health · 2024Article
- Phenotype clustering of hospitalized high-risk patients with COVID-19 - a machine learning approach within the multicentre, multinational PCHF-COVICAV registry.Cardiology journal · 2024Article
- Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand.Frontiers in public health · 2024Article
- Making the Improbable Possible: Generalizing Models Designed for a Syndrome-Based, Heterogeneous Patient Landscape.Critical care clinics · 2023Review
- Risk Factors Associated with COVID-19 Lethality: A Machine Learning Approach Using Mexico Database.Journal of medical systems · 2023Article
- Hyperparameter optimization for cardiovascular disease data-driven prognostic system.Visual computing for industry, biomedicine, and art · 2023Article
- Real-life comparison of mortality in patients with SARS-CoV-2 infection at risk for clinical progression treated with molnupiravir or nirmatrelvir plus ritonavir during the Omicron era in Italy: a nationwide, cohort study.The Lancet regional health. Europe · 2023Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
107 authors at 20 institutions in 1 country.
Augusto Di CastelnuovoMediterranea Cardiocentro, Napoli, Italy.
Marialaura BonaccioDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
Simona CostanzoDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
Alessandro GialluisiDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
Andrea AntinoriUOC Immunodeficienze Virali, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Nausicaa BerselliSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Lorenzo BlandiIRCCS Policlinico San Donato, San Donato Milanese, Italy.
Raffaele BrunoDivision of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic, and Paediatric Sciences, University of Pavia, Pavia, Italy.
Roberto CaudaFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
Giovanni GuaraldiInfectious Disease Unit, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Ilaria MyHumanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
Lorenzo MenicantiIRCCS Policlinico San Donato, San Donato Milanese, Italy.
Giustino ParrutiDepartment of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
Giuseppe PattiUniversity of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.
Stefano PerliniEmergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; Department of Internal Medicine, University of Pavia, Pavia, Italy.
Francesca SantilliDepartment of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
Carlo SignorelliSchool of Medicine, Vita-Salute San Raffaele University, Milano, Italy.
Giulio G StefaniniHumanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
Alessandra VergoriHIV/AIDS Department, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Roma, Italy.
Amina AbdeddaimUOC Malattie Infettive-Epatologia, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
Walter AgenoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Antonella AgodiDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, AOU Policlinico "G. Rodolico - San Marco", Catania, Italy.
Piergiuseppe AgostoniCentro Cardiologico Monzino IRCCS, Milano, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.
Luca AielloUOC Anestesia e Rianimazione. Dipartimento di Chirurgia Generale Ospedale Morgagni-Pierantoni Forlì, Italy.
Samir Al MoghaziUOC Infezioni Sistemiche dell'Immunodepresso, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
Filippo AucellaFondazione I.R.C.C.S "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Greta BarbieriDepartment of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
Alessandro BartoloniDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
Carolina BolognaOspedale del Mare, ASL NA1, Naples, Italy.
Paolo BonfantiUOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Serena BrancatiDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Francesco CacciatoreDepartment of Translational Medical Sciences. University of Naples, Federico II, Naples, Italy.
Lucia CaianoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Francesco CannataHumanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
Laura CarrozziCardiovascular and Thoracic Department, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
Antonio CascioInfectious and Tropical Diseases Unit- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) - University of Palermo, Palermo, Italy.
Antonella CingolaniFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
Francesco CipolloneDepartment of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
Claudia ColombaInfectious and Tropical Diseases Unit- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) - University of Palermo, Palermo, Italy.
Annalisa CrisettiFondazione I.R.C.C.S "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Francesca CrostaDepartment of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
Gian B DanziDepartment of Cardiology, Ospedale di Cremona, Cremona, Italy.
Damiano D'ArdesDepartment of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
Katleen de Gaetano DonatiFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Francesco Di GennaroMedical Direction, IRCCS Neuromed, Pozzilli, IS, Italy.
Gisella Di PalmaUOC Medicina - PO S. Maria di Loreto Nuovo -ASL Napoli 1 Centro, Napoli, Italy.
Giuseppe Di TanoDepartment of Cardiology, Ospedale di Cremona, Cremona, Italy.
Massimo FantoniFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
Tommaso FilippiniSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Paola FiorettoClinica Medica 3, Department of Medicine - DIMED, University hospital of Padova, Padova, Italy.
Francesco M FuscoUOC Infezioni Sistemiche e dell'Immunodepresso, Azienda Ospedaliera dei Colli, Ospedale Cotugno, Napoli, Italy.
Ivan GentileDepartment of Clinical Medicine and Surgery, University of Naples "Federico II". Napoli, Italy.
Leonardo GrisafiUniversity of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.
Gabriella GuarnieriRespiratory Pathophysiology Division, Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Francesco LandiUOC Anestesia e Rianimazione. Dipartimento di Chirurgia Generale Ospedale Morgagni-Pierantoni Forlì, Italy.
Giovanni LarizzaCOVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
Armando LeoneUOC di Pneumologia, P.O. San Giuseppe Moscati, Taranto, Italy.
Gloria MaccagniDepartment of Cardiology, Ospedale di Cremona, Cremona, Italy.
Sandro MaccarellaASST Milano Nord - Ospedale Edoardo Bassini, Cinisello Balsamo, Italy.
Massimo MapelliCentro Cardiologico Monzino IRCCS, Milano, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.
Riccardo MaragnaDepartment of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.
Rossella MarcucciDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
Giulio MarescaCentro Cardiologico Monzino IRCCS, Milano, Italy; UOC Medicina - PO S. Maria di Loreto Nuovo -ASL Napoli 1 Centro, Napoli, Italy.
Claudia MarottaMedical Direction, IRCCS Neuromed, Pozzilli, IS, Italy.
Lorenzo MarraUOC di Pneumologia, P.O. San Giuseppe Moscati, Taranto, Italy.
Franco MastroianniCOVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
Alessandro MengozziDepartment of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
Francesco MenichettiDepartment of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
Jovana MilicInfectious Disease Unit, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Rita MurriFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
Arturo MontineriU.O. C. Malattie Infettive e Tropicali, P.O. "San Marco", AOU Policlinico "G. Rodolico - San Marco", Catania, Italy.
Roberta MussinelliDepartment of Internal Medicine, University of Pavia, Pavia, Italy.
Cristina MussiniInfectious Disease Unit, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Maria MussoUOC Malattie Infettive-Apparato Respiratorio, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Anna OdoneSchool of Medicine, Vita-Salute San Raffaele University, Milano, Italy.
Marco OlivieriComputer Service, University of Molise, Campobasso, Italy.
Emanuela PasiMedicina Interna. Ospedale di Ravenna. AUSL della Romagna, Ravenna, Italy.
Francesco PetriUOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy.
Biagio PincheraDepartment of Clinical Medicine and Surgery, University of Naples "Federico II". Napoli, Italy.
Carlo A PivatoHumanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
Roberto PizziDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Venerino PolettiUOC Pneumologia, Dipartimento di Malattie Apparato Respiratorio e Torace, Ospedale Morgagni-Pierantoni Forlì, Forlì, Italy.
Francesca RaffaelliFondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Claudia RavagliaUOC Pneumologia, Dipartimento di Malattie Apparato Respiratorio e Torace, Ospedale Morgagni-Pierantoni Forlì, Forlì, Italy.
Giulia RighettiCOVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
Andrea RognoniCoronary Care Unit and Catheterization Laboratory, A.O.U. Maggiore della Carità, Novara, Italy.
Marco RossatoClinica Medica 3, Department of Medicine - DIMED, University hospital of Padova, Padova, Italy.
Marianna RossiUOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy.
Anna SabenaEmergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Francesco SalinaroEmergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Vincenzo SangiovanniUOC Infezioni Sistemiche e dell'Immunodepresso, Azienda Ospedaliera dei Colli, Ospedale Cotugno, Napoli, Italy.
Carlo SanroccoDepartment of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
Antonio ScarafinoCOVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
Laura ScorzoliniUOC Malattie Infettive ad Alta Intensità di Cura, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Raffaella SgarigliaASST Milano Nord - Ospedale Edoardo Bassini, Cinisello Balsamo, Italy.
Paola G SimeoneDepartment of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
Enrico SpinoniUniversity of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.
Carlo TortiInfectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences "Magna Graecia" University, Catanzaro, Italy.
Enrico M TrecarichiInfectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences "Magna Graecia" University, Catanzaro, Italy.
Francesca VezzaniDepartment of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
Giovanni VeronesiDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Roberto VettorClinica Medica 3, Department of Medicine - DIMED, University hospital of Padova, Padova, Italy.
Andrea VianelloRespiratory Pathophysiology Division, Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Marco VincetiSection of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Department of Epidemiology, Boston University School of Public Health, Boston, USA.
Raffaele De CaterinaCardiovascular and Thoracic Department, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
Licia IacovielloDepartment of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: licia.iacoviello@moli-sani.org.
COvid-19 RISk and Treatments (CORIST) collaboration
Istituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Neurologico Mediterraneo · ITUniversity of Modena and Reggio Emilia · ITUniversity of Padua · ITASL Roma · ITIRCCS Humanitas Research Hospital · ITOspedale G.B. Morgagni - L.Pierantoni · ITOspedale Generale Regionale Francesco Miulli · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Chieti-Pescara · ITUniversity of Insubria · ITUniversity of Pisa · ITIstituti Ospitalieri di Cremona · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITUniversity of Naples Federico II · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliera San Gerardo · ITAzienda Ospedaliera S.Giuseppe Moscati · ITCasa Sollievo della Sofferenza · ITCentro Cardiologico Monzino · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThere is poor knowledge on characteristics, comorbidities and laboratory measures associated with risk for adverse outcomes and in-hospital mortality in European Countries. We aimed at identifying baseline characteristics predisposing COVID-19 patients to in-hospital death. METHODS AND
resultsRetrospective observational study on 3894 patients with SARS-CoV-2 infection hospitalized from February 19th to May 23rd, 2020 and recruited in 30 clinical centres distributed throughout Italy. Machine learning (random forest)-based and Cox survival analysis. 61.7% of participants were men (median age 67 years), followed up for a median of 13 days. In-hospital mortality exhibited a geographical gradient, Northern Italian regions featuring more than twofold higher death rates as compared to Central/Southern areas (15.6% vs 6.4%, respectively). Machine learning analysis revealed that the most important features in death classification were impaired renal function, elevated C reactive protein and advanced age. These findings were confirmed by multivariable Cox survival analysis (hazard ratio (HR): 8.2; 95% confidence interval (CI) 4.6-14.7 for age ≥85 vs 18-44 y); HR = 4.7; 2.9-7.7 for estimated glomerular filtration rate levels <15 vs ≥ 90 mL/min/1.73 m
conclusionsImpaired renal function, elevated C-reactive protein and advanced age were major predictors of in-hospital death in a large cohort of unselected patients with COVID-19, admitted to 30 different clinical centres all over Italy.
Indexed as
BetacoronavirusHospital MortalityMachine LearningAdolescentAdultAgedAged, 80 and overAge FactorsCardiovascular DiseasesCoronavirus InfectionsCOVID-19C-Reactive ProteinFemaleGlomerular Filtration RateHumansMaleC-Reactive ProteinCOVID-19EpidemiologyIn-hospital mortalityRisk factors
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Registered trials
NCT04907890ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.