Evidence map›Paper›PMID 32912433›Full record

ArticleBioorganic & medicinal chemistry2020

Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites.

Kwaku Kyei-Baffour, Dexter C Davis, Zarko Boskovic, Nobutaka Kato, Mingji Dai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kwaku Kyei-BaffourDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Dexter C DavisDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Zarko BoskovicDepartment of Medicinal Chemistry, University of Kansas, Lawrence, 66045 KS, USA.
Nobutaka KatoBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: nobutaka.kato@GHDDI.org.
Mingji DaiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: mjdai@purdue.edu.
Purdue University West Lafayette · USBroad Institute · USCenter for Cancer Research · USUniversity of Kansas · US

Funding

Synthesis and Study of Medicinally Important MoleculesR35GM128570 · NIGMS · PURDUE UNIVERSITY · PI Mingji Dai · 2018 to 2026
$3.7M
NIGMS NIH HHS R35 GM128570
6 · The paper itself

Abstract

Malaria is a prevalent and deadly disease. The fast emergence of drug-resistant malaria parasites makes the situation even worse. Thus, developing new chemical entities, preferably with novel mechanisms of action, is urgent and important. Inspired by the complex and scarce isonitrile-containing terpene natural products, we evaluated a collection of easily prepared synthetic mono- and bis-isonitrile compounds, most of which feature a simple, but rigid stilbene backbone. From this collection, potent antimalarial lead compounds with EC

Indexed as

AntimalarialsBiological ProductsDose-Response Relationship, DrugDrug ResistanceMolecular StructureNitrilesParasitic Sensitivity TestsPlasmodium falciparumStructure-Activity RelationshipAntimalarialsBiological ProductsNitrilesAntimalarialDrug discoveryDrug resistanceIsonitrileNatural productStilbeneTerpene Isonitrile

Identifiers

PMID32912433
PMCPMC7509796
OpenAlexW3046227554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.