Evidence map›Paper›PMID 32912298›Full record

ArticleTrials2020

Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial.

Huanfang Xu, Chensi Zheng, Liyun He, Tongsheng Su, Huidan Wang, Yu Li, Cui Zhao, Cuilian Zhang, Yang Bai, Guoqing Tong and 8 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Huanfang XuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Chensi ZhengInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Liyun HeInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Tongsheng SuShanxi Provincial Hospital of Chinese Medicine, Taiyuan, Shanxi, China.
Huidan WangShandong University Reproductive Hospital, Jinan, Shandong, China.
Yu LiSun Yat-sen Memorial Hospital of the Sun Yat-sen University, Guangzhou, Guangdong, China.
Cui ZhaoLanzhou University First Hospital, Lanzhou, Gansu, China.
Cuilian ZhangHenan Provincial People's Hospital, Zhengzhou, Henan, China.
Yang BaiHuazhong University of Science and Technology Reproductive Medicine Center of Tongji Medical College, Wuhan, Hubei, China.
Guoqing TongShanghai Shuguang Hospital, Shanghai, China.
Li ChenEast Region Military Command General Hospital, Nanjing, Jiangsu, China.
Fang ZhaoLuoyang Women and Children Health Care Center, Luoyang, Henan, China.
Huisheng YangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Mingzhao HaoInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Yaqian YinInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Li YangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Yigong FangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China. fangyigong@163.com.
Baoyan LiuInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. liuby5505@139.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNHenan Provincial People's Hospital · CNHuazhong University of Science and Technology · CNLanzhou University · CNNanjing General Hospital of Nanjing Military Command · CNShandong Maternal and Child Health Hospital · CNShanxi Province Hospital of Traditional Chinese Medicine · CNShuguang Hospital · CNSun Yat-sen University · CN

Funding

National Key Research and Development Program 2017YFC1703600
6 · The paper itself

Abstract

backgroundPoor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR.

methodsThis will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates, and high-quality embryo rates. The safety of acupuncture will also be assessed. DISCUSSION: The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians.

trial registrationAMCTR-IPR-18000198 . Registered on 10 August 2018.

Indexed as

Acupuncture TherapyOvarian ReserveEmbryo TransferFemaleFertilization in VitroHumansMulticenter Studies as TopicOvulation InductionPregnancyPregnancy RateRandomized Controlled Trials as TopicAcupunctureIn vitro fertilization-embryo transferNumber of retrieved oocytesPoor ovarian responseRandomized controlled trial

Identifiers

PMID32912298
PMCPMC7488258
OpenAlexW3086587467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.