ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2020
Carotid geometry is an independent predictor of wall thickness - a 3D cardiovascular magnetic resonance study in patients with high cardiovascular risk.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Data driven approach to identify vulnerable plaques in carotid atherosclerosis using computed tomography imaging and computational fluid dynamics: A pilot study.PLOS digital health · 2026Article
- Pathophysiology of Atherosclerotic Carotid Disease.Seminars in neurology · 2026Review
- Comparison of deep learning reconstruction algorithms to improve image quality of dual-energy carotid CT angiography under dual-low scan.Neuroradiology · 2026Article
- Carotid atherosclerotic lesion analysis in 3D based on distance encoding in mesh representation.International journal of computer assisted radiology and surgery · 2025Article
- High Wall Shear Stress Is Related to Complicated American Heart Association Lesion Type VI Plaques in Mild-to-Moderate ICA Stenosis: A 3D Cardiovascular MRI Study.AJNR. American journal of neuroradiology · 2025Article
- Carotid artery hemodynamics and geometry as predictors of cerebral small vessel disease: insights from 4D flow imaging.Neuroradiology · 2025Article
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Local artery geometry characteristics associated with middle cerebral atherosclerotic stenosis.Neuroradiology · 2025Article
- Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters.Heliyon · 2024Article
- Learning carotid vessel wall segmentation in black-blood MRI using sparsely sampled cross-sections from 3D data.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- The hemodynamic and geometric characteristics of carotid artery atherosclerotic plaque formation.Quantitative imaging in medicine and surgery · 2024Article
- Carotid geometry is independently associated with complicated carotid artery plaques.Frontiers in cardiovascular medicine · 2023Article
- The Predictors of Asymptomatic Cerebral Embolism After Carotid Artery Stenting.Anatolian journal of cardiology · 2022Article
- Wall Shear Stress Alteration: a Local Risk Factor of Atherosclerosis.Current atherosclerosis reports · 2022Review
- Influence of Carotid Intima-Media Thickness Levels at Bifurcation on Short-Term Functional Outcomes Among Non-Cardiogenic Ischemic Stroke Patients with and without Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Geometrical characteristics associated with atherosclerotic disease in the basilar artery: a magnetic resonance vessel wall imaging study.Quantitative imaging in medicine and surgery · 2021Article
- Carotid Geometry and Wall Shear Stress Independently Predict Increased Wall Thickness-A Longitudinal 3D MRI Study in High-Risk Patients.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe posterior wall of the proximal internal carotid artery (ICA) is the predilection site for the development of stenosis. To optimally prevent stroke, identification of new risk factors for plaque progression is of high interest. Therefore, we studied the impact of carotid geometry and wall shear stress on cardiovascular magnetic resonance (CMR)-depicted wall thickness in the ICA of patients with high cardiovascular disease risk.
methodsOne hundred twenty-one consecutive patients ≥50 years with hypertension, ≥1 additional cardiovascular risk factor and ICA plaque ≥1.5 mm thickness and < 50% stenosis were prospectively included. High-resolution 3D-multi-contrast (time of flight, T1, T2, proton density) and 4D flow CMR were performed for the assessment of morphological (bifurcation angle, ICA/common carotid artery (CCA) diameter ratio, tortuosity, and wall thickness) and hemodynamic parameters (absolute/systolic wall shear stress (WSS), oscillatory shear index (OSI)) in 242 carotid bifurcations.
resultsWe found lower absolute/systolic WSS, higher OSI and increased wall thickness in the posterior compared to the anterior wall of the ICA bulb (p < 0.001), whereas this correlation disappeared in ≥10% stenosis. Higher carotid tortuosity (regression coefficient = 0.764; p < 0.001) and lower ICA/CCA diameter ratio (regression coefficient = - 0.302; p < 0.001) were independent predictors of increased wall thickness even after adjustment for cardiovascular risk factors. This association was not found for bifurcation angle, WSS or OSI in multivariate regression analysis.
conclusionsHigh carotid tortuosity and low ICA diameter were independent predictors for wall thickness of the ICA bulb in this cross-sectional study, whereas this association was not present for WSS or OSI. Thus, consideration of geometric parameters of the carotid bifurcation could be helpful to identify patients at increased risk of carotid plaque generation. However, this association and the potential benefit of WSS measurement need to be further explored in a longitudinal study.
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