Evidence map›Paper›PMID 32912214›Full record

ArticleJournal of nanobiotechnology2020

Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells.

Lucie Sancey, Odile Sabido, Zhiguo He, Fabien Rossetti, Alain Guignandon, Valérie Bin, Jean-Luc Coll, Michèle Cottier, François Lux, Olivier Tillement and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lucie SanceyInstitute for Advanced Biosciences, INSERM U1209, CNRS, UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France. lucie.sancey@univ-grenoble-alpes.fr.ORCID http://orcid.org/0000-0002-0084-3775
Odile SabidoINSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
Zhiguo HeUniversité de Lyon, Saint-Etienne, France.
Fabien RossettiInstitut Lumière Matière, CNRS UMR5306, Université Lyon 1, 69100, Villeurbanne, France.
Alain GuignandonUniversité de Lyon, Saint-Etienne, France.
Valérie BinINSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
Jean-Luc CollInstitute for Advanced Biosciences, INSERM U1209, CNRS, UMR 5309, Université Grenoble Alpes, 38000, Grenoble, France.
Michèle CottierINSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France.
François LuxInstitut Lumière Matière, CNRS UMR5306, Université Lyon 1, 69100, Villeurbanne, France.
Olivier TillementInstitut Lumière Matière, CNRS UMR5306, Université Lyon 1, 69100, Villeurbanne, France.
Samuel ConstantEpithelix SARL, Geneva, Switzerland.
Christophe MasOncoTheis SARL, Geneva, Switzerland.
Delphine BoudardINSERM U1059, Laboratoire SAINBIOSE, équipe DVH/PIB, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, France. delphine.boudard@univ-st-etienne.fr.
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-12-RPIB-0010
6 · The paper itself

Abstract

Liquid deposit mimicking surface aerosolization in the airway is a promising strategy for targeting bronchopulmonary tumors with reduced doses of nanoparticle (NPs). In mimicking and studying such delivery approaches, the use of human in vitro 3D culture models can bridge the gap between 2D cell culture and small animal investigations. Here, we exposed airway epithelia to liquid-apical gadolinium-based AGuIX

Indexed as

A549 CellsAnimalsCell Culture TechniquesCell CycleCell ProliferationDrug Delivery SystemsEpitheliumGadoliniumHumansLungLung NeoplasmsNanoparticlesRespiratory SystemAGuIXGadolinium3D human healthy and tumor airway modelsAGuIX® nanoparticlesNanoparticle’s toxicityNanoparticle’s uptakeTumor targeting

Identifiers

PMID32912214
PMCPMC7488087
OpenAlexW3083870561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.