Evidence map›Paper›PMID 32912147›Full record

ArticleBMC nephrology2020

Diabetes prevalence and outcomes in hospitalized cardiorenal-syndrome patients with and without hyponatremia.

Rainer U Pliquett, Katrin Schlump, Andreas Wienke, Babett Bartling, Michel Noutsias, Alexander Tamm, Matthias Girndt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rainer U PliquettDepartment of Internal Medicine II, Martin - Luther University Halle-Wittenberg, Halle (Saale), Germany. rpliquett@endothel.de.ORCID 0000-0001-9684-0618
Katrin SchlumpDepartment of Internal Medicine II, Martin - Luther University Halle-Wittenberg, Halle (Saale), Germany.
Andreas WienkeInstitute of Medical Epidemiology, Biometry and Informatics, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Babett BartlingUniversity Clinic and Outpatient Clinic for Cardiac Surgery, Martin - Luther University Halle-Wittenberg, Halle (Saale), Germany.
Michel NoutsiasUniversity Clinic and Outpatient Clinic for Internal Medicine III, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Alexander TammUniversity Clinic and Outpatient Clinic for Internal Medicine III, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Matthias GirndtDepartment of Internal Medicine II, Martin - Luther University Halle-Wittenberg, Halle (Saale), Germany.
Martin Luther University Halle-Wittenberg · DECarl-Thiem-Klinikum Cottbus · DEUniversity of Applied Sciences Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyponatremia is known to be associated with a worse patient outcome in heart failure. In cardiorenal syndrome (CRS), the prognostic role of concomitant hyponatremia is unclear. We sought to evaluate potential risk factors for hyponatremia in patients with CRS presenting with or without hyponatremia on hospital admission.

methodsIn a retrospective study, we investigated 262 CRS patients without sepsis admitted to the University Hospital Halle over a course of 4 years. CRS diagnosis was derived from an electronic search of concomitant diagnoses of acute or chronic (NYHA 3-4) heart failure and acute kidney injury (AKIN 1-3) or chronic kidney disease (KDIGO G3-G5

resultsTwo hundred sixty-two CRS patients were included in this study, thereof, 90 CRS patients (34.4%) with hyponatremia (Na < 135 mmol/L). The diabetes prevalence among CRS patients was high (> 65%) and not related to the serum sodium concentration on admission. In comparison to non-hyponatremic CRS patients, the hyponatremic patients had a lower serum osmolality, hypovolemia was more prevalent (41.1% versus 16.3%, p < 0.001). As possible causes of hypovolemia, diarrhea, a higher number of diuretic drug classes and higher diuretic dosages were found. Hyponatremic and non-hyponatremic CRS patients had a comparable need for renal-replacement therapy (36.7% versus 31.4%) during the hospital stay. However, after discharge, relatively more hyponatremic CRS patients on renal replacement therapy switched to a non-dialysis therapy regimen (50.0% versus 22.2%). Hyponatremic CRS patients showed a trend for a higher in-hospital mortality (15.6% versus 7.6%, p = 0.054), but no difference in the one-year mortality (43.3% versus 40.1%, p = 0.692).

conclusionsAll CRS patients showed a high prevalence of diabetes mellitus and a high one-year mortality. In comparison to non-hyponatremic CRS patients, hyponatremic ones were more likely to have hypovolemia, and had a higher likelihood for temporary renal replacement therapy.

Indexed as

MortalityAgedAged, 80 and overCardio-Renal SyndromeDiabetes MellitusFemaleHospitalizationHumansHyponatremiaHypovolemiaMaleMiddle AgedPrevalenceRenal Replacement TherapyRetrospective StudiesCardiorenal syndromeDiabetes mellitusHyponatremiaHypovolemia

Identifiers

PMID32912147
PMCPMC7488139
OpenAlexW3084269803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.