Evidence map›Paper›PMID 32912065›Full record

ArticleCirculation research2020

Xin Bi, Takashi Kuwano, Paul C Lee, John S Millar, Li Li, Yachen Shen, Raymond E Soccio, Nicholas J Hand, Daniel J Rader

Open access · bronzeAbstract read
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xin BiDivision of Translational Medicine and Human Genetics, Department of Medicine (X.B., T.K., P.C.L., J.S.M., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Takashi KuwanoDivision of Translational Medicine and Human Genetics, Department of Medicine (X.B., T.K., P.C.L., J.S.M., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Paul C LeeDivision of Translational Medicine and Human Genetics, Department of Medicine (X.B., T.K., P.C.L., J.S.M., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
John S MillarDivision of Translational Medicine and Human Genetics, Department of Medicine (X.B., T.K., P.C.L., J.S.M., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Li LiCardiovascular Institute (L.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Yachen ShenDepartment of Medicine (Y.S., R.E.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Raymond E SoccioDepartment of Medicine (Y.S., R.E.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Nicholas J HandDepartment of Genetics (X.B., N.J.H., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Daniel J RaderDivision of Translational Medicine and Human Genetics, Department of Medicine (X.B., T.K., P.C.L., J.S.M., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Translational Therapeutics (United States) · USUniversity of Pennsylvania · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
Molecular mechanisms and pathways of novel genomic loci regulating plasma lipidsRC2HL101864 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2009 to 2010
$4.7M
Genetics of Elevated High Density Lipoprotein CholesterolR01HL089309 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2008 to 2012
$3.9M
NHLBI NIH HHS R01 HL089309NHLBI NIH HHS RC2 HL101864NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

rationaleSingle-nucleotide polymorphisms near the

objectiveTo investigate the role of ILRUN in plasma lipid and lipoprotein metabolism. METHODS AND

results

conclusionsThese findings establish ILRUN as a novel regulator of lipid metabolism that promotes hepatic lipoprotein production. Our results also provide functional evidence that

Indexed as

AnimalsBlood GlucoseCell Line, TumorChlorocebus aethiopsCholesterol, HDLCOS CellsGene Expression RegulationGlucose IntoleranceHEK293 CellsHepatocytesHumansLipoproteinsLipoproteins, VLDLLiverMaleMice, Inbred C57BLBlood GlucoseCholesterol, HDLILRUN protein, humanLipoproteinsLipoproteins, VLDLNeoplasm ProteinsPPAR alphaPpara protein, mouseRetinoid X Receptor alphaTriglyceridesvery low density lipoprotein triglyceridecholesterolhepatocyteslipidslipoproteinsmetabolismubiquitin

Identifiers

PMID32912065
PMCPMC7644615
OpenAlexW3086690628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.