Evidence map›Paper›PMID 32911863›Full record

ArticlePharmaceutics2020

Development of Theranostic Cationic Liposomes Designed for Image-Guided Delivery of Nucleic Acid.

Hai Doan Do, Christine Ménager, Aude Michel, Johanne Seguin, Tawba Korichi, Hélène Dhotel, Corinne Marie, Bich-Thuy Doan, Nathalie Mignet

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hai Doan DoUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Christine MénagerSorbonne Université, Laboratoire PHENIX (Physicochimie des Electrolytes et Nanosystèmes Interfaciaux), CNRS, 4 place Jussieu, F-75005 Paris, France.
Aude MichelSorbonne Université, Laboratoire PHENIX (Physicochimie des Electrolytes et Nanosystèmes Interfaciaux), CNRS, 4 place Jussieu, F-75005 Paris, France.
Johanne SeguinUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Tawba KorichiUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Hélène DhotelUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Corinne MarieUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Bich-Thuy DoanChimie ParisTech PSL Research University, Institute of Chemistry for Life and Health Sciences (i-CleHS), SEISAD, F-75005 Paris, France.
Nathalie MignetUniversité de Paris, UTCBS (Chemical and Biological Technologies for Health Unit), CNRS, INSERM, 75006 Paris, France.
Centre National de la Recherche Scientifique · FRChimie ParisTech · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic liposomes have been considered as potential vectors for gene delivery thanks to their ability to transfect cells with high efficiency. Recently, the combination of diagnostic agent and therapeutic agents in the same particle to form a theranostic system has been reported. Magnetic liposomes are one of these examples. Due to the magnetic nanoparticles encapsulated in the liposomes, they can act as a drug delivery system and, at the same time, a magnetic resonance imaging contrast enhancement agent or hyperthermia. In this work, nucleic acid delivery systems based on magnetic cationic liposomes (MCLs) were developed. Two different techniques, reverse phase evaporation and cosolvent sonication, were employed for liposome preparation. Both strategies produced MCLs of less than 200 nm with highly positive charge. Enhancement of their transverse and longitudinal relaxivities

Indexed as

magnetic cationic liposomemagnetic targetingmagnetofectionMRInucleic acid delivery

Identifiers

PMID32911863
PMCPMC7559777
OpenAlexW3084138667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.