Evidence map›Paper›PMID 32911859›Full record

ArticleInternational journal of molecular sciences2020

Discovery of

Wondossen Sime, Mohamed Jemaà, Yasmin Abassi, Vito Alessandro Lasorsa, Julie Bonne Køhler, Karin Hansson, Daniel Bexell, Martin Michaelis, Jindrich Cinatl, Daniel Strand and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Wondossen SimeDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.ORCID 0000-0001-9518-2457
Mohamed JemaàDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.ORCID 0000-0003-4905-1020
Yasmin AbassiDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.
Vito Alessandro LasorsaDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
Julie Bonne KøhlerDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.
Karin HanssonDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.
Daniel BexellDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.
Martin MichaelisSchool of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0002-5710-5888
Jindrich CinatlInstitute of Medical Virology, Clinics of the Goethe-University, D-60596 Frankfurt am Main, Germany.
Daniel StrandCentre for Analysis and Synthesis, Department of Chemistry, Lund University, 221 00 Lund, Sweden.ORCID 0000-0002-6113-4657
Mario CapassoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.ORCID 0000-0003-3306-1259
Ramin MassoumiDepartment of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, 223 81 Lund, Sweden.ORCID 0000-0001-8875-6440
Lund University · SECeinge Biotecnologie Avanzate (Italy) · ITGoethe University Frankfurt · DESDN Istituto di Ricerca Diagnostica e Nucleare · ITUniversity of Kent · GB

Funding

Cancerfonden ---European Research Council 260460Gunnar Nilssons Cancerstiftelse ---Magnus Bergvalls Stiftelse ---
6 · The paper itself

Abstract

Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule,

Indexed as

AnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell SurvivalDoxorubicinDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFemaleHigh-Throughput Screening AssaysHumansMiceMice, NudeNeuroblastomaPyridinesSmall Molecule LibrariesAntineoplastic AgentsDoxorubicinPyridinesSmall Molecule LibrariesVincristineapoptosischemoresistanceepi-enpriolineneuroblastomavincristine

Identifiers

PMID32911859
PMCPMC7556009
OpenAlexW3084360337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.