ArticleCancers2020
The Effect of Resection Margin on Local Recurrence and Survival in High Grade Soft Tissue Sarcoma of the Extremities: How Far Is Far Enough?
Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Staged Resection with Temporizing VAC and Local Recurrence for Soft Tissue Sarcomas: A Multi-Institutional Review.Cancers · 2026Article
- Advancements in Skeletal Tumour Management: Linking Metastatic Biology With Surgical Reconstruction.Cureus · 2026Review
- Machine learning and logistic regression in estimating survival in patients with high-malignant deep-seated soft tissue sarcomas: development and analysis based on a population-based retrospective cohort.Acta orthopaedica · 2026Article
- Prognostic factors and survival outcomes in patients undergoing limb-sparing surgery for primary malignant bone tumors.Frontiers in oncology · 2026Article
- Rethinking tumor viability as prognostic factor in soft tissue sarcoma.Journal of orthopaedics · 2025Article
- Beyond the benign: A rare case report of myxoid pleomorphic liposarcoma.Radiology case reports · 2025Article
- The Impact of Resection Margins in Primary Resection of High-Grade Soft Tissue Sarcomas: How Far Is Far Enough?Biomedicines · 2025Article
- Brachytherapy for Soft Tissue Sarcoma: Maintaining Local Control While Minimizing Complications.Journal of surgical oncology · 2025Article
- The Impact of Surgical Margin Distance on Local Recurrence and Survival in Patients with Soft Tissue Sarcoma.Medicina (Kaunas, Lithuania) · 2025Article
- The impact of margins and re-resection in pediatric synovial sarcoma.Cancer medicine · 2024Article
- The Effect of chemo- and radiotherapy on tumor necrosis in soft tissue sarcoma- does it influence prognosis?BMC cancer · 2024Article
- Article
- Lymphadenectomy in the treatment of sarcomas - indications and technique.Oncology reviews · 2024Review
- Synovial sarcoma in the prevertebral space can mimic malignant neurogenic neoplasm: Case report and literature review.Radiology case reports · 2023Article
- Undifferentiated soft-tissue sarcoma (STS) in a 34-year-old woman: A case report.International journal of surgery case reports · 2023Article
- Local relapse of soft tissue sarcoma of the extremities or trunk wall operated on with wide margins without radiation therapy.BJS open · 2023Article
- Synovial sarcomas: A single surgeon experience of 130 cases.Journal of surgical oncology · 2022Article
- The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma.Radiation oncology (London, England) · 2022Article
- Preoperative Planning Using Three-Dimensional Multimodality Imaging for Soft Tissue Sarcoma of the Axilla: A Pilot Study.Cancers · 2022Article
- The Outcome of Extremity Soft Tissue Sarcomas in Terms of Resection Margins: A Study From a Cancer Dedicated Center.Cureus · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe significance of surgical margins after resection of soft tissue sarcomas in respect to local-recurrence-free survival and overall survival is evaluated.
methodsA total of 305 patients with deep-seated, G2/3 soft tissue sarcomas (STS) of the extremity, the trunk wall, or the pelvis were reviewed. The margin was defined according to the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) classification system (R0-2), the Union Internationale Contre le Cancer (UICC) classification (R + 1 mm) for which a margin <1 mm is included into the R1 group, and in groups of <1 mm, 1-5 mm, >5 mm, or >10 mm.
resultsOf these patients, 31 (10.2%) had a contaminated margin, 64 (21%) a margin of <1 mm, 123 (40.3%) a margin of 1-5 mm, 47 (15.4%) a margin of >5 mm, and 40 (13.1%) a margin of >10 mm. The 5-year local recurrence-free survival (LRFS) was 81.6%. Overall survival (OS) at 5 years was 65.9%. Positive margins worsened LRFS and OS. A margin of >10 mm did not improve LRFS and OS as compared to one of >5 mm.
conclusionsA resection margin of <1 mm showed a trend but not significantly better LRFS or OS compared to a contaminated margin. This finding supports use of the UICC classification. A margin of more than 10 mm did not improve LRFS or OS.
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