Evidence map›Paper›PMID 32911777›Full record

ReviewToxins2020

Venom Ophthalmia and Ocular Complications Caused by Snake Venom.

Kun-Che Chang, Yu-Kai Huang, Yen-Wen Chen, Min-Hui Chen, Anthony T Tu, Yen-Chia Chen

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Case Report of Rattlesnake Musk Exposure Causing Chemical Conjunctivitis.Clinical practice and cases in emergency medicine · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. The Chinese guideline for management of snakebites.World journal of emergency medicine · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Kun-Che ChangSpencer Center for Vision Research, Byers Eye Institute, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.ORCID 0000-0002-0871-5612
Yu-Kai HuangGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yen-Wen ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Min-Hui ChenEnkang Clinic, New Taipei 23144, Taiwan.
Anthony T TuDepartment of Biochemistry and Molecular Biology, Colorado State University, Ft. Collins, CO 80523, USA.
Yen-Chia ChenEmergency Department, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
National Yang Ming Chiao Tung University · TWColorado State University · USKaohsiung Medical University · TWUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the detailed clinical description, pathophysiology, and efficacy of treatments for ocular envenoming (venom ophthalmia) caused by venom of the spitting elapid and other snakes, as well as ocular complications caused by snake venom injection. In this paper, we review clinical information of case reports regarding venom ophthalmia and snake venom injection with associated ocular injuries in Asia, Africa, and the United States. We also review the literature of snake venom such as their compositions, properties, and toxic effects. Based on the available clinical information and animal studies, we further discuss possible mechanisms of venom ophthalmia derived from two different routes (Duvernoy's gland in the mouth and nuchal gland in the dorsal neck) and the pathophysiology of snake venom injection induced ocular complications, including corneal edema, corneal erosion, cataract, ocular inflammation, retinal hemorrhage, acute angle closure glaucoma, as well as ptosis, diplopia, and photophobia. Finally, we discuss the appropriate first aid and novel strategies for treating venom ophthalmia and snake envenoming.

Indexed as

AerosolsAnimalsAntiveninsEndophthalmitisEyeHumansPrognosisSnake BitesSnakesSnake VenomsAerosolsAntiveninsSnake Venomscorneal edemanuchal glandretinal hemorrhagesnakebitesnake venomspitting venom

Identifiers

PMID32911777
PMCPMC7551025
OpenAlexW3084314114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.