ArticleInternational journal of molecular sciences2020
Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Engineering anisotropic tissues: from structured scaffolds to magnetic actuation.Materials today. Bio · 2026Review
- Magnetic Bioprinting and Actuation of Stretchable Muscle Tissue.Advanced healthcare materials · 2026Article
- Collagen Fibril Orientation In Vitro: From Formation to Advanced Biomaterial Development.Biomimetics (Basel, Switzerland) · 2025Review
- Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.Science advances · 2025Article
- Effect of a Constant Magnetic Field on Cell Morphology and Migration Mediated by Cytoskeleton-Bound Magnetic Nanoparticles.International journal of molecular sciences · 2025Article
- A comprehensive approach to characterize navigation instruments for magnetic guidance in biological systems.Scientific reports · 2024Article
- Optical Microscopy Using the Faraday Effect RevealsACS nano · 2024Article
- Programming an Enhanced Uptake and the Intracellular Fate of Magnetic Microbeads.Advanced healthcare materials · 2023Article
- Surface Tension and Neuronal Sorting in Magnetically Engineered Brain-Like Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients.Journal of the Royal Society, Interface · 2022Article
- Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells.Frontiers in medical technology · 2022Article
- Magnetic Nanoparticle-Mediated Orientation of Collagen Hydrogels for Engineering of Tendon-Mimetic Constructs.Frontiers in bioengineering and biotechnology · 2022Article
- Article
- Self-Assembled Permanent Micro-Magnets in a Polymer-Based Microfluidic Device for Magnetic Cell Sorting.Cells · 2021Article
- Magnetic spatiotemporal control of SOS1 coupled nanoparticles for guided neurite growth in dopaminergic single cells.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
Abstract
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles appears to be promising, since magnetic fields can act at a distance without interactions with the surrounding biological system. To control biological processes at a subcellular spatial resolution, magnetic nanoparticles can be used either to induce biochemical reactions locally or to apply forces on different elements of the cell. Here, we show that cell migration and neurite outgrowth can be directed by the forces produced by a switchable parallelized array of micro-magnetic pillars, following the passive uptake of nanoparticles. Using live cell imaging, we first demonstrate that adherent cell migration can be biased toward magnetic pillars and that cells can be reversibly trapped onto these pillars. Second, using differentiated neuronal cells we were able to induce events of neurite outgrowth in the direction of the pillars without impending cell viability. Our results show that the range of forces applied needs to be adapted precisely to the cellular process under consideration. We propose that cellular actuation is the result of the force on the plasma membrane caused by magnetically filled endo-compartments, which exert a pulling force on the cell periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.