Evidence map›Paper›PMID 32911646›Full record

ReviewMolecules (Basel, Switzerland)2020

Tackling Resistance to Cancer Immunotherapy: What Do We Know?

Soehartati A Gondhowiardjo, Handoko, Vito Filbert Jayalie, Riyan Apriantoni, Andreas Ronald Barata, Fajar Senoaji, Igaa Jayanthi Wulan Utami, Ferdinand Maubere, Endang Nuryadi, Angela Giselvania

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Soehartati A GondhowiardjoFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.ORCID 0000-0002-9446-4361
HandokoFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.ORCID 0000-0002-2834-9090
Vito Filbert JayalieFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.ORCID 0000-0002-4314-9740
Riyan ApriantoniFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.
Andreas Ronald BarataFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.
Fajar SenoajiFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.
Igaa Jayanthi Wulan UtamiFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.
Ferdinand MaubereFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.ORCID 0000-0003-4182-9176
Endang NuryadiFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.
Angela GiselvaniaFaculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.ORCID 0000-0002-3396-0660
University of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer treatment has evolved tremendously in the last few decades. Immunotherapy has been considered to be the forth pillar in cancer treatment in addition to conventional surgery, radiotherapy, and chemotherapy. Though immunotherapy has resulted in impressive response, it is generally limited to a small subset of patients. Understanding the mechanisms of resistance toward cancer immunotherapy may shed new light to counter that resistance. In this review, we highlighted and summarized two major hurdles (recognition and attack) of cancer elimination by the immune system. The mechanisms of failure of some available immunotherapy strategies were also described. Moreover, the significance role of immune compartment for various established cancer treatments were also elucidated in this review. Then, the mechanisms of combinatorial treatment of various conventional cancer treatment with immunotherapy were discussed. Finally, a strategy to improve immune cancer killing by characterizing cancer immune landscape, then devising treatment based on that cancer immune landscape was put forward.

Indexed as

Drug Resistance, NeoplasmImmunotherapyAnimalsAntigen PresentationAntigens, NeoplasmChemotaxis, LeukocyteCombined Modality TherapyHLA AntigensHumansImmune Checkpoint InhibitorsLymphocyte ActivationNeoplasmsT-LymphocytesTreatment OutcomeTumor EscapeTumor MicroenvironmentAntigens, NeoplasmHLA AntigensImmune Checkpoint Inhibitorsantigen presentationcancerimmune checkpointimmune escapeimmunosuppressionimmunotherapyresistanceT celltreatment

Identifiers

PMID32911646
PMCPMC7570938
OpenAlexW3084138469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.