Evidence map›Paper›PMID 32911641›Full record

ReviewCells2020

Calcium, Bioenergetics, and Parkinson's Disease.

Enrico Zampese, D James Surmeier

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05855577 (-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients), which is not on this map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05855577 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

-Clinical Efficacy of Pharmacological Treatments Targeting Energy Metabolism, Evaluated by Gait Analysis, on Motor Function in Parkinson's Disease Patients

TypeinterventionalSponsorI.R.C.C.S. Fondazione Santa LuciaRan2023 to 2026Enrolled50ConditionsParkinson Disease, Gait Analysis, Therapy, Directly Observed, Metabolic DiseaseArmsTerazosin
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Enrico ZampeseDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-8851-2566
D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Northwestern University · US

Funding

SYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KRAINC, DIMITRI · 2003 to 2018
$19.2M
NINDS NIH HHS P50 NS047085
6 · The paper itself

Abstract

Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca

Indexed as

CalciumEnergy MetabolismHumansOxidative StressParkinson DiseaseCalciumbioenergeticsCa2+dopaminergic neuronsmitochondrianeurodegenerationoxidative stressParkinson’s diseasesubstantia nigra

Identifiers

PMID32911641
PMCPMC7564460
OpenAlexW3083790931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.