Evidence map›Paper›PMID 32911601›Full record

ArticleJournal of clinical medicine2020

Changed Profile of Serum Transferrin Isoforms in Primary Biliary Cholangitis.

Agnieszka Grytczuk, Alicja Bauer, Ewa Gruszewska, Bogdan Cylwik, Lech Chrostek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Agnieszka GrytczukDepartment of Laboratory Diagnostics, University Clinical Hospital, 15-540 Bialystok, Poland.
Alicja BauerDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.ORCID 0000-0003-2051-1177
Ewa GruszewskaDepartment of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Bogdan CylwikDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, 15-274 Bialystok, Poland.
Lech ChrostekDepartment of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland.
Medical University of Białystok · PLPostgraduate School of Molecular Medicine · PLUniversity Clinical Hospital In Bialystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver damage affects the synthesis of proteins and glycoproteins, and alters their posttranslational modification, such as glycosylation changing the serum profile of glycoprotein isoforms. The retention of hydrophobic bile acids in the course of cholestatic liver diseases is a major cause of liver damage in primary biliary cholangitis (PBC). The study objective was to determine the serum profile of transferrin isoforms in primary biliary cholangitis and compare it to transferrin isoforms profile in extrahepatic cholestasis. The study was carried out in 76 patients with PBC and 40 healthy blood donors. Transferrin isoforms were analyzed by the capillary electrophoresis method. The mean relative concentrations of disialotransferrin and trisialotransferrin in PBC were significantly lower than those in the healthy subjects (

Indexed as

capillary electrophoresisglycosylationprimary biliary cholangitistransferrin isoforms

Identifiers

PMID32911601
PMCPMC7564153
OpenAlexW3083664302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.