Evidence map›Paper›PMID 32911598›Full record

ArticleBiomolecules2020

Ranking Series of Cancer-Related Gene Expression Data by Means of the Superposing Significant Interaction Rules Method.

Emili Besalú, Jesus Vicente De Julián-Ortiz

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emili BesalúInstitut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, 17003 Girona, Spain.ORCID 0000-0003-0093-5714
Jesus Vicente De Julián-OrtizMolecular Topology and Drug Design Research Unit, Departament de Química Física, Facultat de Farmàcia, Universitat de València, 46100 Burjassot, Spain.ORCID 0000-0001-9403-8744

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Superposing Significant Interaction Rules (SSIR) method is a combinatorial procedure that deals with symbolic descriptors of samples. It is able to rank the series of samples when those items are classified into two classes. The method selects preferential descriptors and, with them, generates rules that make up the rank by means of a simple voting procedure. Here, two application examples are provided. In both cases, binary or multilevel strings encoding gene expressions are considered as descriptors. It is shown how the SSIR procedure is useful for ranking the series of patient transcription data to diagnose two types of cancer (leukemia and prostate cancer) obtaining Area Under Receiver Operating Characteristic (AU-ROC) values of 0.95 (leukemia prediction) and 0.80-0.90 (prostate). The preferential selected descriptors here are specific gene expressions, and this is potentially useful to point to possible key genes.

Indexed as

AlgorithmsData Interpretation, StatisticalData MiningGene Expression ProfilingHumansLeukemiaMaleOligonucleotide Array Sequence AnalysisPattern Recognition, AutomatedProstatic NeoplasmsROC CurveStructure-Activity Relationshipcancergene expressionsleukemiamultilevel fingerprintsprostate cancerrankingSSIR method

Identifiers

PMID32911598
PMCPMC7564041

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.