Evidence map›Paper›PMID 32911595›Full record

ArticleInternational journal of molecular sciences2020

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model.

Naseer Ahmed, Javeria Farooq, Soban Sadiq, Sultan Ayoub Meo, Azam Jan, Faisal H Cheema, Giuseppe Faggian, Alessio Rungatscher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Protecting the Mitochondria in Cardiac Disease.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Naseer AhmedDepartment of Biological and Biomedical Sciences, The Aga Khan University, Karachi 74800, Pakistan.ORCID 0000-0001-8724-0039
Javeria FarooqDepartment of Biological and Biomedical Sciences, The Aga Khan University, Karachi 74800, Pakistan.ORCID 0000-0001-9645-0417
Soban SadiqFaculty of Medicine, Imperial College London, London SW72AZ, UK.
Sultan Ayoub MeoDepartment of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0001-9820-1852
Azam JanDepartment of Cardiac Surgery, Rehman Medical Institute, Peshawar 25000, Pakistan.
Faisal H CheemaDepartment of Biomedical Sciences, University of Houston College of Medicine, Houston, TX 77004, USA.
Giuseppe FaggianDepartment of Surgery, Cardiac Surgery Division, University of Verona Medical School, 37129 Verona, Italy.ORCID 0000-0001-5371-5761
Alessio RungatscherDepartment of Surgery, Cardiac Surgery Division, University of Verona Medical School, 37129 Verona, Italy.
Aga Khan University · PKUniversity of Verona · ITImperial College London · GBKing Saud University · SAUniversity of Houston · US

Funding

King Saud University RVP-VPP-181
6 · The paper itself

Abstract

During heart transplantation, donor heart leads to reduced oxygen supply resulting in low level of high energy phosphate (HEP) reserves in cardiomyocyte. Lower HEP is one of the underlying reasons of cell death due to ischemia. In this study we investigated the role of Fingolimod (FTY720) in heart transplantation ischemia. Eight groups of Sprague-Dawley rats (

Indexed as

AnimalsCoronary Artery DiseaseCoronary CirculationFingolimod HydrochlorideHeartHeart TransplantationMyocardial IschemiaMyocardial Reperfusion InjuryPhosphatesPoly(ADP-ribose) PolymerasesRatsRats, Sprague-DawleyFingolimod HydrochloridePhosphatesPoly(ADP-ribose) Polymerasescardiac functioncoronary blood flowfingolimod (FTY720)high energy phosphatespoly (ADP ribose) polymerase

Identifiers

PMID32911595
PMCPMC7554839
OpenAlexW3083506749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.