ArticleClinical and experimental reproductive medicine2020
Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax.
Article in Clinical and experimental reproductive medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of Total Flavonoids FromFood science & nutrition · 2026Article
- L-carnitine mitigates urographin-induced nephrotoxicity via modulation of inflammatory, oxidative, and apoptotic pathways in rat kidney.Molecular and cellular biochemistry · 2026Article
- Zingerone Mitigates Testicular Dysfunction Induced by Cisplatin.JBRA assisted reproduction · 2026Article
- Potential Anticancer Effect ofInternational journal of molecular sciences · 2025Article
- Carnitine Deficiency in Chronic Kidney Disease: Pathophysiology, Clinical Implications, and Therapeutic Perspectives.Nutrients · 2025Review
- Article
- Bitter acids from Humulus lupulus L. alleviate D-galactose induced osteoblastic senescence and bone loss via regulating AKT/mTOR-mediated autophagy.Journal of food and drug analysis · 2024Article
- The effect of L-carnitine in reactive oxygen species reduction and apoptotic gene expression in mice after cyclophosphamide: An experimental study.International journal of reproductive biomedicine · 2024Article
- Thymoquinone effects on autophagy, apoptosis, and oxidative stress in cisplatin-induced testicular damage in mice.Journal of assisted reproduction and genetics · 2024Article
- L-Carnitine and Male Fertility: Is Supplementation Beneficial?Journal of clinical medicine · 2023Review
- Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment.Parasites & vectors · 2022Article
- Cryopreservation of Pig Semen Using a Quercetin-Supplemented Freezing Extender.Life (Basel, Switzerland) · 2022Article
- Antioxidant Activity and Oxidative Stress-Oriented Apoptosis Pathway in Saccharides Supplemented Cryopreserved Sperm of Pacific Abalone,Antioxidants (Basel, Switzerland) · 2022Article
- [Regulatory effects and signaling mechanism of sodium ferulate on the proliferation and apoptosis of human skin hypertrophic scar fibroblasts].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Royal-jelly-based apitherapy can attenuate damages to male reproductive parameter following nicotine administration.Animal models and experimental medicine · 2022Article
- Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols.Antioxidants (Basel, Switzerland) · 2021Review
- The effects of L-carnitine on renal function and gene expression of caspase-9 and Bcl-2 in monosodium glutamate-induced rats.BMC nephrology · 2021Article
- L-carnitine in a certain concentration increases expression of cell surface marker CD34 and apoptosis in the rat bone marrow CD34Iranian journal of veterinary research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe genes Bcl-2 and Bax play important roles in apoptosis. Many studies have shown that formalin has a strong deleterious effect on male fertility and can induce apoptosis. L-carnitine has been reported to potentially reverse the negative effects of formalin, leading to improved spermatogenesis. In this study, we examined the levels of expression of Bcl-2 and Bax in mice treated with formalin and L-carnitine.
methodsThirty adult BALB/c mice were categorized into three groups. The mice in the control group (n=10) were not injected with any substance. The mice in the second group (n=10) received 10 mg/kg of formalin daily via an intraperitoneal injection, while those in the final group (n=10) were intraperitoneally injected daily with a dose of 10 mg/kg of formalin and 100 mg/kg of L-carnitine. All mice were kept in isolated cages for 31 days.
resultsThe expression of Bax was significantly higher in the formalin-treated mice than in the mice of the control group, while the expression of Bcl-2 was significantly lower in the formalin-treated mice than in the control mice. Additionally, relative to control mice, Bcl-2 expression increased and Bax expression decreased in the mice administered both formalin and L-carnitine.
conclusionIn this study, L-carnitine was shown to augment Bcl-2 expression and to reduce Bax expression, indicating that this compound may inhibit apoptosis. Due to its positive effects, L-carnitine can be used as a prophylactic treatment for people who routinely come into direct contact with formalin as an occupational hazard.
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