ArticlePLoS neglected tropical diseases2020
Dengue infection modulates locomotion and host seeking in Aedes aegypti.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Making scents of mosquito lures: semiochemical attractants for adult mosquitoes.Parasites & vectors · 2026Review
- Progress in research on mosquito-borne viruses: Understanding infection, transmission, and control.Infectious diseases & immunity · 2026Review
- Impact of insecticide resistance on controlling mosquito vectors and its potential contribution to behavioural modifications.Malaria journal · 2025Review
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- Hematophagy Generates a Convergent Genomic Signature in Mosquitoes and Sandflies.Genome biology and evolution · 2025Article
- The impact of blood on vector-borne diseases with emphasis on mosquitoes and sand flies.Trends in parasitology · 2025Review
- Dengue-mediated changes in the vectorial capacity of Aedes aegypti (Diptera: Culicidae): manipulation of transmission or infection by-product?Journal of medical entomology · 2025Review
- Zika virus does not alter locomotor activity of Aedes albopictus (Diptera: Culicidae).Revista de saude publica · 2025Article
- High vector competence for chikungunya virus but heavily reduced locomotor activity of Aedes albopictus from Germany at low temperatures.Parasites & vectors · 2024Article
- FlightTrackAI: a robust convolutional neural network-based tool for tracking the flight behaviour ofRoyal Society open science · 2024Article
- À la carte: how mosquitoes choose their blood meals.Trends in parasitology · 2024Review
- Localization of nitric oxide-producing hemocytes in Aedes and Culex mosquitoes infected with bacteria.Cell and tissue research · 2024Article
- Dehydration and tomato spotted wilt virus infection combine to alter feeding and survival parameters for the western flower thrips,Current research in insect science · 2024Article
- No detectable fitness cost of infection by cell-fusing agent virus inRoyal Society open science · 2024Article
- Evaluation of insemination, blood feeding, and Plasmodium vivax infection effects on locomotor activity patterns of the malaria vector Anopheles darlingi (Diptera: Culicidae).Parasitology research · 2023Article
- Pathogen-Mediated Alterations of Insect Chemical Communication: From Pheromones to Behavior.Pathogens (Basel, Switzerland) · 2023Review
- Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors.PLoS neglected tropical diseases · 2023Article
- Chikungunya Virus Infection and Gonotrophic Cycle ShapeViruses · 2023Article
- Influence of RVFV Infection on Olfactory Perception and Behavior inPathogens (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens may manipulate their human and mosquito hosts to enhance disease transmission. Dengue, caused by four viral serotypes, is the fastest-growing transmissible disease globally resulting in 50-100 million infections annually. Transmission of the disease relies on the interaction between humans and the vector Aedes aegypti and is largely dependent on the odor-mediated host seeking of female mosquitoes. In this study, we use activity monitors to demonstrate that dengue virus-1 affects the locomotion and odor-mediated behavior of Ae. aegypti, reflecting the progression of infection within the mosquito. Mosquitoes 4-6 days post-infection increase locomotion, but do not alter their odor-driven host-seeking response. In contrast, females 14-16 days post-infection are less active, yet more sensitive to human odors as assessed by behavioral and electrophysiological assays. Such an increase in physiological and behavioral sensitivity is reflected by the antennal-specific increase in abundance of neural signaling transcripts in 14 days post-infection females, as determined by transcriptome analysis. This suggests that the sensitivity of the mosquito peripheral olfactory system is altered by the dengue virus by enhancing the overall neural responsiveness of the antenna, rather than the selective regulation of chemosensory-related genes. Our study reveals that dengue virus-1 enhances vector-related behaviors in the early stages post-infection that aid in avoiding predation and increasing spatial exploration. On the other hand, at the later stages of infection, the virus enhances the host-seeking capacity of the vector, thereby increasing the risk of virus transmission. A potential mechanism is discussed.
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