ArticleJournal of psychosomatic research2020
Different independent associations of depression and anxiety with survival in patients with cancer.
Article in Journal of psychosomatic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.GeroScience · 2026Pooled it
- The impact of anxiety and depression on hematologic malignancy outcomes: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data.International journal of colorectal disease · 2024Pooled it
- Trial
- The Experience of Depression in Older Adults With Cancer: A Qualitative Descriptive Analysis.Psycho-oncology · 2026Article
- Association between depression and low skeletal muscle mass in patients with newly diagnosed lung cancer.Frontiers in psychology · 2026Article
- Molecular mechanisms and clinical value of the correlation between depression and cancer.Medical oncology (Northwood, London, England) · 2025Review
- Modulating Gut Microbiota with Dietary Components: A Novel Strategy for Cancer-Depression Comorbidity Management.Nutrients · 2025Review
- Psychosocial distress, perceived need and utilization of psycho- social support services in patients in the early phase after the first cancer diagnosis.Journal of cancer research and clinical oncology · 2025Article
- New highlights in cancer and depression multimorbidity: a scoping systematic review.Frontiers in oncology · 2025Review
- Reduction of death anxiety in patients with advanced cancer in short-term psychotherapy.Frontiers in psychology · 2025Article
- Lung cancer patients' illness perceptions: Prognostic for psychological and physical health trajectories.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Observational
- Screening for depression and anxiety in lung cancer patients: A real-world study using GAD-7 and HADS.Thoracic cancer · 2024Article
- Association of dietary inflammatory index and systemic inflammatory markers with mortality risk in depressed adults: a mediation analysis of NHANES data.Frontiers in nutrition · 2024Article
- Dyadic effects of social support, illness uncertainty on anxiety and depression among lung cancer patients and their caregivers: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- The relationship of social determinants and distress in newly diagnosed cancer patients.Scientific reports · 2023Article
- Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study.Social psychiatry and psychiatric epidemiology · 2023Article
- Assessment of preoperative anxiety and depression in patients with pulmonary ground-glass opacities: Risk factors and postoperative outcomes.Frontiers in surgery · 2023Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveDepression and anxiety have both been reported to predict worse subsequent survival in people with cancer. However, depression and anxiety are mutually associated and we lack understanding of their independent associations with survival. We therefore aimed to investigate these in a large sample of patients with common cancers.
methodsWe analysed data on 19,966 patients with common cancers (breast, colorectal, gynaecological, lung and prostate) who had attended specialist NHS outpatient clinics in Scotland, UK. Hospital Anxiety and Depression Scale (HADS) data were linked with demographic, cancer and mortality data. We estimated the independent associations of depression (HADS depression score) and anxiety (HADS anxiety score) with survival by fitting (separately for each cancer) Cox proportional hazards models which incorporated cubic splines to allow for non-linear associations. We also adjusted for potential confounders.
resultsThe median time from HADS completion to death or censoring was 1.9 years. Greater depression was found to be strongly associated with worse survival from all cancers. When adjusted for anxiety, this association remained in males and increased in females. Greater anxiety was also associated with worse survival in nearly all cancers. However, when adjusted for depression, the association of anxiety with worse survival was lost. In females the association reversed direction so that greater anxiety was associated with better survival.
conclusionAlthough often considered together as aspects of 'emotional distress', depression and anxiety have different independent associations with survival in patients with cancer and should therefore be considered separately.
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