Evidence map›Paper›PMID 32911331›Full record

ArticleiScience2020

Timescales of Human Hair Cortisol Dynamics.

Lior Maimon, Tomer Milo, Rina S Moyal, Avi Mayo, Tamar Danon, Anat Bren, Uri Alon

Open access · goldAbstract read
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Measurement of Hair Cortisol Throughout Gestation.Journal of clinical medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lior MaimonDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Tomer MiloDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Rina S MoyalDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Avi MayoDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Tamar DanonDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Anat BrenDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Uri AlonDepartment Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.
Weizmann Institute of Science · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortisol is a major human stress hormone, secreted within minutes of acute stress. Cortisol also has slower patterns of variation: a strong circadian rhythm and a seasonal rhythm. However, longitudinal cortisol dynamics in healthy individuals over timescales of months has rarely been studied. Here, we measured longitudinal cortisol in 55 healthy participants using 12 cm of hair, which provides a retrospective measurement over one year. Individuals showed (non-seasonal) fluctuations averaging about 22% around their baseline. Fourier analysis reveals dominant slow frequencies with periods of months to a year. These frequencies can be explained by a mathematical model of the hormonal cascade that controls cortisol, the HPA axis, when including the slow timescales of tissue turnover of the glands. Measuring these dynamics is important for understanding disorders in which cortisol secretion is impaired over months, such as mood disorders, and to test models of cortisol feedback control.

Indexed as

Biological SciencesChronobiologyHuman Metabolism

Identifiers

PMID32911331
PMCPMC7490542
OpenAlexW3081428631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.