Evidence map›Paper›PMID 32911193›Full record

ArticleBioorganic chemistry2020

Development of activity-based probes for the protein deacylase Sirt1.

Christopher J Goetz, Daniel J Sprague, Brian C Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher J GoetzDepartment of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Daniel J SpragueDepartment of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Brian C SmithDepartment of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: brismith@mcw.edu.
Medical College of Wisconsin · US

Funding

Discovering and Exploiting Selectivity within Tandem BromodomainsR35GM128840 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Brian Christopher Smith · 2018 to 2026
$2.7M
American Heart Association-American Stroke Association 15SDG25830057NIGMS NIH HHS R35 GM128840
6 · The paper itself

Abstract

Sirtuins are NAD

Indexed as

Drug DevelopmentCells, CulturedDose-Response Relationship, DrugHEK293 CellsHumansMolecular ProbesMolecular StructurePeptidesSirtuin 1Structure-Activity RelationshipMolecular ProbesPeptidesSIRT1 protein, humanSirtuin 1Activity-based probeAcylationClick chemistryDeacylaseEnzyme catalysisPeptidesPhotoaffinity labelingSirtuinS-nitrosation

Identifiers

PMID32911193
PMCPMC7686039
OpenAlexW3081094631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.