Evidence map›Paper›PMID 32910955›Full record

ArticleAntiviral research2020

Structural-based virtual screening and in vitro assays for small molecules inhibiting the feline coronavirus 3CL protease as a surrogate platform for coronaviruses.

Sirin Theerawatanasirikul, Chih Jung Kuo, Nanthawan Phecharat, Jullada Chootip, Chalermpol Lekcharoensuk, Porntippa Lekcharoensuk

Open access · greenAbstract read
In one paragraph

Article in Antiviral research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. First study onVeterinary world · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sirin TheerawatanasirikulDepartment of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.
Chih Jung KuoDepartment of Veterinary Medicine, National Chung Hsing University, Taichung, 40227, Taiwan. Electronic address: ck476@nchu.edu.tw.
Nanthawan PhecharatDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.
Jullada ChootipDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.
Chalermpol LekcharoensukDepartment of Companion Animals Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.
Porntippa LekcharoensukDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand; Center of Advanced Studies in Agriculture and Food, KU Institute, Thailand. Electronic address: fvetptn@ku.ac.th.
Kasetsart University · THNational Chung Hsing University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline infectious peritonitis (FIP) which is caused by feline infectious peritonitis virus (FIPV), a variant of feline coronavirus (FCoV), is a member of family Coronaviridae, together with severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2. So far, neither effective vaccines nor approved antiviral therapeutics are currently available for the treatment of FIPV infection. Both human and animal CoVs shares similar functional proteins, particularly the 3CL protease (3CL

Indexed as

Amino Acid SequenceAnimalsAntiviral AgentsBetacoronavirusCatalytic DomainCatsCoronavirus 3C ProteasesCoronavirus, FelineCoronavirus InfectionsCOVID-19Cysteine EndopeptidasesCysteine Proteinase InhibitorsDrug Evaluation, PreclinicalFeline Infectious PeritonitisHumansInhibitory Concentration 50Antiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesCysteine Proteinase InhibitorsSmall Molecule LibrariesViral Nonstructural ProteinsAntiviral activityCoVs surrogateFeline infectious peritonitis virus (FIP)Small moleculesVirtual screening

Identifiers

PMID32910955
PMCPMC7476565
OpenAlexW3083361439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.