SynthesisThe Journal of pediatrics2021
Community-Onset Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Young Infants: A Systematic Review.
Synthesis in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Clinical characteristics and risk factors of severe COVID-19 in hospitalized neonates with omicron variant infection: a retrospective study.Italian journal of pediatrics · 2024Article
- Bacterial coinfection in young febrile infants with SARS-CoV-2 infection.European journal of pediatrics · 2024Article
- Clinical Syndromes Related to SARS-CoV-2 Infection and Vaccination in Pediatric Age: A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- The Clinical Course of Coronavirus Disease 2019 Under 2 Years of Age.Turkish archives of pediatrics · 2023Article
- Clinical Epidemiology of Pediatric Coronavirus Disease 2019 and its Postacute Sequelae.Seminars in respiratory and critical care medicine · 2023Review
- COVID-19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic.Pediatric pulmonology · 2023Review
- Severe encephalopathy associated with SARS-CoV-2 Omicron BA.1 variant infection in a neonate.Brain & development · 2022Article
- Favorable Outcome in Infants Hospitalized With COVID-19: Single Center Experience from Athens, Greece.Indian pediatrics · 2022Article
- COVID-19 Infection in Well-Appearing 30- to 90-Day-Old Infants with Fever without a Source.Journal of tropical pediatrics · 2022Article
- Clinical features and outcomes of coronavirus disease 2019 in early infants in Japan: A case series and literature review.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Review
- Long-term physical, mental and social health effects of COVID-19 in the pediatric population: a scoping review.World journal of pediatrics : WJP · 2022Article
- Markers for severe disease and long-term sequelae in pediatric patients with severe acute respiratory syndrome coronavirus 2 infection.Pediatrics international : official journal of the Japan Pediatric Society · 2022Article
- Clinical Manifestations and Complications of Children With COVID-19 Compared to Other Respiratory Viral Infections: A Cohort Inpatient Study From Rio de Janeiro, Brazil.Frontiers in pediatrics · 2022Article
- Risk factors for admission to the pediatric critical care unit among children hospitalized with COVID-19 in France.Frontiers in pediatrics · 2022Article
- Comparison of SARS-CoV-2-Specific Antibodies in Human Milk after mRNA-Based COVID-19 Vaccination and Infection.Vaccines · 2021Article
- Innovative design of 3D-printed nasopharyngeal pediatric swab for COVID-19 detection.3D printing in medicine · 2021Article
- Community-Acquired Neonatal SARS-CoV-2 Infection Associated with Neurological Symptoms in Colombia.Journal of tropical pediatrics · 2021Article
- COVID-19 Pandemic: Different Associative Relationships of City Lockdown With Preterm Births in Three Cities - An Ecological Study.Frontiers in pediatrics · 2021Article
- Risk factors for severe COVID-19 infection in Brazilian children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo summarize and evaluate current reports on community-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young infants. STUDY
designWe performed a systematic review to identify reports published from November 1, 2019, until June 15, 2020, on laboratory-confirmed community-onset SARS-CoV-2 infection in infants younger than 3 months of age. We excluded studies reporting neonates with perinatal coronavirus disease 2019 (COVID-19) exposure and diagnosis before hospital discharge and hospital-onset disease, as well as clinically diagnosed cases without confirmation. Two independent reviewers performed study screening, data abstraction, and risk of bias assessment. Variables of interest included patient age, exposure to COVID-19, medical history, clinical symptoms, SARS-CoV-2 testing, laboratory findings, clinical course, and disposition.
resultsIn total, 38 publications met inclusion criteria, including 23 single case reports, 14 case series, and 1 cohort study, describing 63 infants younger than 3 months of age with laboratory-confirmed SARS-CoV-2 infection. Most cases were mild to moderate. Fever, respiratory, gastrointestinal, cardiac, and neurologic findings were reported. Laboratory abnormalities included neutropenia, lymphopenia, and elevated serum levels of inflammatory markers and aminotransferases. Fifty-eight (92%) infants were hospitalized, 13 (21%) were admitted to the intensive care unit, and 2 (3%) required mechanical ventilation. No death was reported.
conclusionsAmong young infants with laboratory-confirmed SARS-CoV-2 infection, most cases were mild to moderate and improved with supportive care. Our results demonstrate a need for a high index of suspicion for SARS-CoV-2 infection in young infants presenting with generalized symptoms such as fever or decreased feeding, even in the absence of respiratory symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.