Evidence map›Paper›PMID 32910930›Full record

Observational studyThe American journal of cardiology2020

Relation of Low Normal Left Ventricular Ejection Fraction to Heart Failure Hospitalization in Blacks (From the Jackson Heart Study).

Daisuke Kamimura, Karen A Valle, Chad Blackshear, Robert J Mentz, Joseph Yeboah, Carlos J Rodriguez, David M Herrington, Takeki Suzuki, Ⅲ Donald Clark, Ervin R Fox and 6 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Daisuke KamimuraDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: daisukekmmr@gmail.com.
Karen A ValleCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi.
Chad BlackshearCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi.
Robert J MentzDepartment of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, North Carolina.
Joseph YeboahHeart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Carlos J RodriguezHeart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
David M HerringtonHeart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Takeki SuzukiDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Ⅲ Donald ClarkDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Ervin R FoxDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Amil M ShahDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Richard B StaceyHeart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
William G HundleyHeart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Javed ButlerDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · USWake Forest University · USIndiana University School of MedicineDuke University · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOUTON, ALAN J · 2013 to 2022
$23.4M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Quantifying cardiac structure and function to define the progression to hear failure in African AmericansR01HL143224 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M · 2018 to 2021
$3.4M
Renal Sinus Fat, Hypertension, and Altered Kidney FunctionK08DK099415 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, MICHAEL EDWARD · 2015 to 2019
$791k
Systolic & diastolic dysfunction in heart failure and preserved ejection fractionK08HL116792 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAH, AMIL M · 2013 to 2017
$735k
Mentoring patient-oriented research in deep phenotyping of cardiac function for heart failure preventionK24HL152008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAH, AMIL M · 2020 to 2024
$608k
NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL116792NHLBI NIH HHS K24 HL152008NHLBI NIH HHS R01 HL135008NHLBI NIH HHS R01 HL143224NIDDK NIH HHS K08 DK099415NIGMS NIH HHS P20 GM104357NIGMS NIH HHS U54 GM115428NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

There is no clear consensus on a lower cutoff value for normal left ventricular ejection fraction (EF) and the prognostic implications of low normal EF (LNEF) are poorly understood, particularly in Blacks. Therefore, we investigated the association of LNEF and incident heart failure (HF) in a community-based cohort of Blacks. We studied 3,669 participants (mean age 54 years, 63% women) of the Jackson Heart Study without prevalent HF or coronary heart disease (CHD). Participants were divided into three groups: (1) Reduced EF (<50%), (2) LNEF (≥50%, <55%), and (3) Normal EF (≥55%). There were 197 cases of incident HF hospitalizations over a median follow-up of 10 years (interquartile range 9.4 to 10). After adjustment for conventional risk factors and incident CHD, the LNEF group had a higher rate of incident HF hospitalization than the Normal EF group (HR 1.58, 95% CI 1.04 to 2.38, p<0.05). Furthermore, this relation remained statistically significant after additionally adjusting for LV mass index but was not significant after adjusting for LV diastolic dysfunction grade. In participants with LNEF with incident HF, 63% developed HF with reduced EF and 37% developed HF with preserved EF. In conclusion, LNEF is associated with higher risk of incident HF hospitalization in comparison with normal EF in a community-based cohort of Blacks. In those with LNEF who went on to develop HF, most cases were HF with reduced EF. These findings suggest that strategies are needed for risk stratification and management to improve outcomes in patients with LNEF.

Indexed as

Stroke VolumeAdultAgedBlack or African AmericanFemaleHeart FailureHospitalizationHumansLongitudinal StudiesMaleMiddle AgedMississippiProspective StudiesRisk Assessment

Identifiers

PMID32910930
PMCPMC12611556
OpenAlexW3084027787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.