ReviewDiabetes care2020
The Measurement of Insulin Clearance.
Review in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Insulin Sensitivity and Beta Cell Function With Macupatide Alone or With Dulaglutide in Type 2 Diabetes: A Phase 1b, Randomised Controlled Trial.Diabetes, obesity & metabolism · 2026Trial
- Prevention of type 2 diabetes through prediabetes remission without weight loss.Nature medicine · 2025Trial
- Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial.Diabetologia · 2025Trial
- Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab.Diabetologia · 2025Trial
- Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes.Diabetologia · 2024Trial
- Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial.Cell reports. Medicine · 2024Trial
- Exercise mode influences post-exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex-dependent manner: A randomized control trial.Physiological reports · 2022Trial
- β Cell function and plasma insulin clearance in people with obesity and different glycemic status.The Journal of clinical investigation · 2022Trial
- Association of Serum Lithium Levels with Insulin Resistance in Type-2 Diabetes Patients.Biological trace element research · 2026Article
- Association of Serum Lithium Levels with Insulin Resistance in Type-2 Diabetes Patients.Biological trace element research · 2026Article
- Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis.Metabolites · 2026Article
- Higher salivary nitrite is associated with improved glycemic control and insulin sensitivity in patients with type 2 diabetes.Nutrition & metabolism · 2026Article
- Hypoglycemia in diabetes with low-affinity insulin antibody successfully improved by treating sleep apnea syndrome.JCEM case reports · 2026Article
- Micro-needle jet injection technology for tunable drug dispersion at delivery.Drug delivery and translational research · 2026Article
- Comparison of Islet Function in People With Different Glucose Metabolic States.Endocrine, metabolic & immune disorders drug targets · 2026Article
- The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy.Endocrine reviews · 2025Review
- Metabolic Phenotype of Stage 1 and Stage 2 Type 1 Diabetes Using Modeling of β Cell Function.The Journal of clinical endocrinology and metabolism · 2025Article
- Phenotypic patterns of metabolic dysfunction-associated steatotic liver disease in type 2 diabetes: The impact of insulin.European journal of clinical investigation · 2025Observational
- Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity.Diabetes, obesity & metabolism · 2025Article
- Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig.STAR protocols · 2025Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide:insulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extrahepatic). The methods are explored and interpreted by critically highlighting advantages and limitations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.