ArticleEuropean journal of rheumatology2020
Clinical and autoantibody profile in male and female patients with systemic lupus erythematosus: A retrospective study in 603 Brazilian patients.
Article in European journal of rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Sex-based clinical and immunological differences across lupus erythematosus subtypes: a cross-sectional multicentre study from China.Lupus science & medicine · 2026Article
- A Pooled Analysis of Sex Differences in Lupus Nephritis.Kidney international reports · 2026Article
- Article
- Long-term follow-up of Iranian male patients with systemic lupus erythematosus.Clinical and experimental medicine · 2023Article
- Panoramic view of clinical features of lupus erythematosus: a cross-sectional multicentre study from China.Lupus science & medicine · 2023Article
- The landscape of systemic lupus erythematosus in Brazil: An expert panel review and recommendations.Lupus · 2021Review
- Estrogen and estrogen receptors in kidney diseases.Renal failure · 2021Review
- Evaluating Sex Differences in the Characteristics and Outcomes of Lupus Nephritis: A Systematic Review and Meta-Analysis.Glomerular diseasesReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSex and ethnic background may influence the clinical and autoantibody profile in systemic lupus erythematosus (SLE). This retrospective study aimed to compare the clinical and autoantibody profiles of male and female patients with SLE in a sample of Brazilian patients.
methodsThis was a retrospective study of 603 patients (48 males and 555 females) from a single rheumatology center. Collected clinical data included clinical findings according to the definition of 2012 Systemic Lupus International Collaborating Clinics classification criteria, the presence of antiphospholipid antibody syndrome according to the Sydney classification criteria and autoantibody profile (anti-dsDNA, anti-Ro, anti-La, anti-Sm, anti-RNP, rheumatoid factor, anticardiolipin [aCl] IgG, aCl IgM, lupus anticoagulant, and direct antiglobulin test), and histological results of kidney biopsies.
resultsIt was found that females had higher age at disease onset (p=0.02), more oral ulcers (p=0.001), and presented more often with alopecia (p<0.0001) than males. Males had a higher prevalence of glomerulonephritis (OR=6.5; 95%CI=3.0-13.7) and anti-dsDNA (OR=2.59; 95%CI=1.38-4.85) than females, but no differences were found in the pattern of renal biopsies (p=0.46).
conclusionIn this sample of Brazilian patients, the males had more renal involvement, fewer oral ulcers, and presented fewer times with alopecia than females.
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Registered trials
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