Evidence map›Paper›PMID 32910705›Full record

ArticleThe Journal of international medical research2020

Interleukin-37 contributes to the pathogenesis of gout by affecting PDZ domain-containing 1 protein through the nuclear factor-kappa B pathway.

Wei Wan, Yeqing Shi, Lianmei Ji, Xiaofang Li, Xia Xu, Dongbao Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Autoinflammatory Features in Gouty Arthritis.Journal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei WanDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-3506-3330
Yeqing ShiDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.
Lianmei JiDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.
Xiaofang LiDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.
Xia XuDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.
Dongbao ZhaoDepartment of Rheumatology and Immunology, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-3312-024X
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur objective was to explore the molecular pathogenesis of the onset of gout and the mechanism underlying the effect of interleukin (IL)-37 on PDZ domain-containing 1 (PDZK1) protein through the nuclear factor-κB signaling pathway.

methodsReal-time PCR and western blotting were used to detect expression of PDZK1 mRNA and protein, respectively, in the HK-2 cell line. The inhibitors pyrrolidine dithiocarbamate (PDTC) and wortmannin were added to HK-2 cells stimulated by IL-37, and changes in PDZK1 protein were detected by western blotting.

resultsBased on our previous research, we used 10 µmol/L PDTC. We detected no significant change in

conclusionsIL-37 can affect protein expression of PDZK1, but not at the translational level, in the pathogenesis of gout.

Indexed as

GoutNF-kappa BHumansInterleukin-1InterleukinsMembrane ProteinsPDZ DomainsSignal TransductionIL37 protein, humanInterleukin-1InterleukinsMembrane ProteinsNF-kappa BPDZK1 protein, humangoutinflammatoryInterleukin-37mechanismnuclear factor-κB pathwayPDZ domain-containing 1wortmannin

Identifiers

PMID32910705
PMCPMC7488913
OpenAlexW3086688749

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.