Evidence map›Paper›PMID 32910678›Full record

ArticleAmerican journal of speech-language pathology2020

Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.

Eduardo Europa, Leonardo Iaccarino, David C Perry, Elizabeth Weis, Ariane E Welch, Gil D Rabinovici, Bruce L Miller, Maria Luisa Gorno-Tempini, Maya L Henry

Open access · greenAbstract readCase Reports
In one paragraph

Article in American journal of speech-language pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Counseling and Care Partner Training in Primary Progressive Aphasia.Perspectives of the ASHA special interest groups · 2021
    Article
  9. Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eduardo EuropaMemory and Aging Center, University of California, San Francisco.
Leonardo IaccarinoMemory and Aging Center, University of California, San Francisco.
David C PerryMemory and Aging Center, University of California, San Francisco.
Elizabeth WeisMemory and Aging Center, University of California, San Francisco.
Ariane E WelchMemory and Aging Center, University of California, San Francisco.
Gil D RabinoviciMemory and Aging Center, University of California, San Francisco.
Bruce L MillerMemory and Aging Center, University of California, San Francisco.
Maria Luisa Gorno-TempiniMemory and Aging Center, University of California, San Francisco.
Maya L HenryDepartment of Communication Sciences and Disorders, The University of Texas at Austin.
University of California, San Francisco · USThe University of Texas at Austin · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Serggio Carlo Lanata · 2019 to 2026
$36.9M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Purpose Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision. Method We describe the diagnostic evaluation of a 49-year-old woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis. Conclusion Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention. Supplemental Material https://doi.org/10.23641/asha.12771113.

Indexed as

Aphasia, Primary ProgressiveBrainFemaleHumansMagnetic Resonance ImagingMiddle AgedNeuropsychological TestsPositron-Emission TomographySpeech

Identifiers

PMID32910678
PMCPMC8740567
OpenAlexW3045126544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.