ReviewBrain and behavior2020
"Gut-brain axis": Review of the role of the probiotics in anxiety and depressive disorders.
Review in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of probiotic supplementation on cortisol levels; GRADE-based dose-response meta-analysis.BMC nutrition · 2026Pooled it
- The effect of Lactobacillus casei on postpartum depression: a randomized controlled trial.BMC psychiatry · 2025Trial
- High intellectual ability and the gut-brain-sex steroids axis: a perspective on cognitive and emotional diversity.Frontiers in physiology · 2026Article
- The Effect of the Combination of Two Postbiotics on Anxiety-like Behavior in Animal Models.Cells · 2024Article
- Utilization of Probiotic-Derived Extracellular Vesicles as Postbiotics and Their Role in Mental Health Therapeutics.Food science of animal resources · 2024Review
- Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress.Foods (Basel, Switzerland) · 2023Article
- "Gut-brain axis": Review of the role of the probiotics in anxiety and depressive disorders.Brain and behavior · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepressive disorders are the leading cause of disability worldwide and together with anxiety contribute to a very high burden of disease. Therefore, improving their treatment is a significant medical research target: The role of probiotics is a topic of great interest for the current research in this field.
objectivesTo explore the current literature about the impact of probiotics on anxious and depressive symptoms.
methodsScoping review following the PRISMA guidelines.
resultsThe selection process yielded 23 studies. Probiotics positively affected depressive symptomatology and anxiety symptoms according to 53.83% and 43.75% of the selected studies, respectively. Among the studies assessing inflammatory biomarkers, 58.31% found they were decreased after administration of probiotics.
conclusionThe results emerging from the existing literature about probiotic supplementation for depression treatment are encouraging, but further research is needed considering the shortage of clinical trials on this topic and the heterogeneity of the samples analyzed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.