ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020
Physiology-Based Treatment of Myoclonus.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Drug-Induced Myoclonus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Myoclonus as a neurologic manifestation of hypoglycemia in dogs.Journal of veterinary internal medicine · 2026Article
- Phenotypic characterization of presumptive propriospinal myoclonus in young dogs (2013-2025).Journal of veterinary internal medicine · 2026Article
- Cervical spondylosis with propriospinal myoclonus and vocalization: a case report.Frontiers in surgery · 2026Article
- Pharmacotherapeutic Controversies During Temperature Control After Out-of-Hospital Cardiac Arrest: A Semi-Structured Literature Review.Pharmacotherapy · 2026Review
- Article
- Familial adult myoclonus epilepsy: A comprehensive diagnostic strategy for clinical practice.Epilepsia · 2025Review
- Cerebellar and extra-cerebellar symptoms in movement disorders.Arquivos de neuro-psiquiatria · 2025Review
- Article
- Generalized Myoclonus in an Elderly Patient on Risperidone: A Rare but Important Adverse Effect.Case reports in psychiatry · 2025Article
- Clinical Utility of Neurophysiologic Classification (and Declassification) of Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Myoclonus: Differential diagnosis and current management.Epilepsia open · 2024Review
- A Reappraisal on cortical myoclonus and brief Remarks on myoclonus of different Origins.Clinical neurophysiology practice · 2024Review
- Movement disorders in autoimmune encephalitis: an update.Journal of neurology · 2023Review
- Overview of Movement Disorders Secondary to Drugs.Clinics and practice · 2023Review
- Myoclonus Secondary to Amantadine: Case Report and Literature Review.Clinics and practice · 2023Article
- Adult-onset idiopathic opsoclonus-myoclonus syndrome.Arquivos brasileiros de oftalmologia · 2023Article
- Post hypoxic myoclonus: A tale of two minds.Epilepsy & behavior reports · 2023Article
- Successful Treatment of Irinotecan-Induced Muscle Twitching: A Case Report.Clinical medicine insights. Case reports · 2023Article
- Antiseizure Drugs and Movement Disorders.CNS drugs · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myoclonus can cause significant disability for patients. Myoclonus has a strikingly diverse array of underlying etiologies, clinical presentations, and pathophysiological mechanisms. Treatment of myoclonus is vital to improving the quality of life of patients with these disorders. The optimal treatment strategy for myoclonus is best determined based upon careful evaluation and consideration of the underlying etiology and neurophysiological classification. Electrophysiological testing including EEG (electroencephalogram) and EMG (electromyogram) data is helpful in determining the neurophysiological classification of myoclonus. The neurophysiological subtypes of myoclonus include cortical, cortical-subcortical, subcortical-nonsegmental, segmental, and peripheral. Levetiracetam, valproic acid, and clonazepam are often used to treat cortical myoclonus. In cortical-subcortical myoclonus, treatment of myoclonic seizures is prioritized, valproic acid being the mainstay of therapy. Subcortical-nonsegmental myoclonus may be treated with clonazepam, though numerous agents have been used depending on the etiology. Segmental and peripheral myoclonus are often resistant to treatment, but anticonvulsants and botulinum toxin injections may be of utility depending upon the case. Pharmacological treatments are often hampered by scarce evidence-based knowledge, adverse effects, and variable efficacy of medications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.