Evidence map›Paper›PMID 32910374›Full record

ArticleCEN case reports2021

Cervical cancer of the uterus complicated by renal AA amyloidosis.

Hajime Fujisawa, Atsuki Ohashi, Jun Ohta, Naohiro Muraki, Yuta Nakano, Kouhei Sugita, Saori Ishihara, Jiro Kumagai, Toshiyuki Fukutomi, Kiyotaka Nagahama

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Amyloid A Amyloidosis Secondary to Thymoma.Diagnostics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hajime FujisawaDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan. h-fujisawa.med@yokohama.jrc.or.jp.ORCID 0000-0002-1011-9959
Atsuki OhashiDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Jun OhtaDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Naohiro MurakiDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Yuta NakanoDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Kouhei SugitaDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Saori IshiharaDepartment of Nephrology, Yokohama City Minato Red Cross Hospital, 3-12-1 Shinyamashita Nakaku, Yokohama, Kanagawa, Japan.
Jiro KumagaiDepartment of Pathology, Yokohama City Minato Red Cross Hospital, Yokohama, Kanagawa, Japan.
Toshiyuki FukutomiDepartment of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Kiyotaka NagahamaDepartment of Pathology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Yokohama Municipal Minato Red Cross Hospital · JPKyorin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer of the uterus rarely develops systemic secondary amyloidosis. We present the case of a 66-year-old female patient who manifested systemic amyloid A (AA) amyloidosis in the kidney, digestive tract, and cervix of the uterus, secondary to cervical cancer. She exhibited nephrotic syndrome, intractable diarrhea, and mild fever 3 months after she underwent an extended hysterectomy with postoperative cisplatin-based chemotherapy and whole pelvic irradiation. Further examinations revealed AA amyloidosis of the kidney and colon and cytomegalovirus infection in the colon. AA amyloid deposition was positive in the resected tissues of uterine cancer. The patient was diagnosed with systemic AA amyloidosis consecutive to cervical cancer. Despite a decrease in urinary protein after antiviral therapy, it increased 14 months later with neither apparent symptoms nor an increase in tumor marker. A second renal biopsy revealed AA amyloidosis of the kidney. Subsequent investigations revealed the recurrence of cervical cancer in the lung, liver, and lymph nodes. This case report indicated that AA amyloidosis would complicate cervical cancer and recur even after resection of neoplasm owing to other stimulation. Moreover, urine protein could be a marker for cancer relapse in known cases of cancer-derived AA amyloidosis.

Indexed as

AgedAmyloidosisBiopsyChemoradiotherapy, AdjuvantColonCytomegalovirus InfectionsDiarrheaFemaleFeverHumansHysterectomyKidneyNeoplasm Recurrence, LocalNephrotic SyndromePostoperative CareProteinuriaSerum Amyloid A ProteinAA amyloidosisCervical cancerRenal amyloidosis

Identifiers

PMID32910374
PMCPMC7829288
OpenAlexW3085199432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.